Cationic Gold Catalyst Poisoning and Reactivation

[Image: see text] High gold affinity impurities (halides, bases) in solvents, starting materials, filtration, or drying agents could affect the reactivity of gold catalyst adversely, which may significantly reduce the TON of cationic gold-catalyzed reactions. Use of a suitable acid activator (e.g.,...

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Detalles Bibliográficos
Autores principales: Kumar, Manish, Hammond, Gerald B., Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084836/
https://www.ncbi.nlm.nih.gov/pubmed/24937566
http://dx.doi.org/10.1021/ol501663f
Descripción
Sumario:[Image: see text] High gold affinity impurities (halides, bases) in solvents, starting materials, filtration, or drying agents could affect the reactivity of gold catalyst adversely, which may significantly reduce the TON of cationic gold-catalyzed reactions. Use of a suitable acid activator (e.g., HOTf, In(OTf)(3)) reactivates the gold catalyst and makes the reaction proceed smoothly at low gold catalyst loading.

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