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Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants

[Image: see text] Five different mutants of [Leu-5] Enkephalin YGGFL peptide have been investigated for fibril formation propensities. The early oligomer structures have been probed with a combination of ion-mobility mass spectrometry and computational modeling. The two peptides YVIFL and YVVFL form...

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Detalles Bibliográficos
Autores principales:	Do, Thanh D., LaPointe, Nichole E., Sangwan, Smriti, Teplow, David B., Feinstein, Stuart C., Sawaya, Michael R., Eisenberg, David S., Bowers, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084844/ https://www.ncbi.nlm.nih.gov/pubmed/24915112 http://dx.doi.org/10.1021/jp502473s

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