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Autocrine Effects of Tumor-Derived Complement
We describe a role for the complement system in enhancing cancer growth. Cancer cells secrete complement proteins that stimulate tumor growth upon activation. Complement promotes tumor growth via a direct autocrine effect that is partially independent of tumor-infiltrating cytotoxic T cells. Activat...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084868/ https://www.ncbi.nlm.nih.gov/pubmed/24613353 http://dx.doi.org/10.1016/j.celrep.2014.02.014 |
| _version_ | 1782324576507658240 |
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| author | Cho, Min Soon Vasquez, Hernan G. Rupaimoole, Rajesha Pradeep, Sunila Wu, Sherry Zand, Behrouz Han, Hee-Dong Rodriguez-Aguayo, Cristian Bottsford-Miller, Justin Huang, Jie Miyake, Takahito Choi, Hyun-Jin Dalton, Heather J. Ivan, Cristina Baggerly, Keith Lopez-Berestein, Gabriel Sood, Anil K. Afshar-Kharghan, Vahid |
| author_facet | Cho, Min Soon Vasquez, Hernan G. Rupaimoole, Rajesha Pradeep, Sunila Wu, Sherry Zand, Behrouz Han, Hee-Dong Rodriguez-Aguayo, Cristian Bottsford-Miller, Justin Huang, Jie Miyake, Takahito Choi, Hyun-Jin Dalton, Heather J. Ivan, Cristina Baggerly, Keith Lopez-Berestein, Gabriel Sood, Anil K. Afshar-Kharghan, Vahid |
| author_sort | Cho, Min Soon |
| collection | PubMed |
| description | We describe a role for the complement system in enhancing cancer growth. Cancer cells secrete complement proteins that stimulate tumor growth upon activation. Complement promotes tumor growth via a direct autocrine effect that is partially independent of tumor-infiltrating cytotoxic T cells. Activated C5aR and C3aR signal through the PI3K/AKT pathway in cancer cells, and silencing the PI3K or AKT gene in cancer cells eliminates the progrowth effects of C5aR and C3aR stimulation. In patients with ovarian or lung cancer, higher tumoral C3 or C5aR mRNA levels were associated with decreased overall survival. These data identify a role for tumor-derived complement proteins in promoting tumor growth, and they therefore have substantial clinical and therapeutic implications. |
| format | Online Article Text |
| id | pubmed-4084868 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40848682014-07-07 Autocrine Effects of Tumor-Derived Complement Cho, Min Soon Vasquez, Hernan G. Rupaimoole, Rajesha Pradeep, Sunila Wu, Sherry Zand, Behrouz Han, Hee-Dong Rodriguez-Aguayo, Cristian Bottsford-Miller, Justin Huang, Jie Miyake, Takahito Choi, Hyun-Jin Dalton, Heather J. Ivan, Cristina Baggerly, Keith Lopez-Berestein, Gabriel Sood, Anil K. Afshar-Kharghan, Vahid Cell Rep Article We describe a role for the complement system in enhancing cancer growth. Cancer cells secrete complement proteins that stimulate tumor growth upon activation. Complement promotes tumor growth via a direct autocrine effect that is partially independent of tumor-infiltrating cytotoxic T cells. Activated C5aR and C3aR signal through the PI3K/AKT pathway in cancer cells, and silencing the PI3K or AKT gene in cancer cells eliminates the progrowth effects of C5aR and C3aR stimulation. In patients with ovarian or lung cancer, higher tumoral C3 or C5aR mRNA levels were associated with decreased overall survival. These data identify a role for tumor-derived complement proteins in promoting tumor growth, and they therefore have substantial clinical and therapeutic implications. 2014-03-06 2014-03-27 /pmc/articles/PMC4084868/ /pubmed/24613353 http://dx.doi.org/10.1016/j.celrep.2014.02.014 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| spellingShingle | Article Cho, Min Soon Vasquez, Hernan G. Rupaimoole, Rajesha Pradeep, Sunila Wu, Sherry Zand, Behrouz Han, Hee-Dong Rodriguez-Aguayo, Cristian Bottsford-Miller, Justin Huang, Jie Miyake, Takahito Choi, Hyun-Jin Dalton, Heather J. Ivan, Cristina Baggerly, Keith Lopez-Berestein, Gabriel Sood, Anil K. Afshar-Kharghan, Vahid Autocrine Effects of Tumor-Derived Complement |
| title | Autocrine Effects of Tumor-Derived Complement |
| title_full | Autocrine Effects of Tumor-Derived Complement |
| title_fullStr | Autocrine Effects of Tumor-Derived Complement |
| title_full_unstemmed | Autocrine Effects of Tumor-Derived Complement |
| title_short | Autocrine Effects of Tumor-Derived Complement |
| title_sort | autocrine effects of tumor-derived complement |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084868/ https://www.ncbi.nlm.nih.gov/pubmed/24613353 http://dx.doi.org/10.1016/j.celrep.2014.02.014 |
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