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Enantiospecific Effects of Ketoconazole on Aryl Hydrocarbon Receptor

Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(−)-KET, we examined the effects of KET enantiomers on AhR signaling pathway. (+)-KET dose-dependently a...

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Detalles Bibliográficos
Autores principales:	Novotna, Aneta, Korhonova, Martina, Bartonkova, Iveta, Soshilov, Anatoly A., Denison, Michael S., Bogdanova, Katerina, Kolar, Milan, Bednar, Petr, Dvorak, Zdenek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084896/ https://www.ncbi.nlm.nih.gov/pubmed/25000292 http://dx.doi.org/10.1371/journal.pone.0101832

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