FOXO3a Potentiates hTERT Gene Expression by Activating c-MYC and Extends the Replicative Life-Span of Human Fibroblast

In our previous studies, we reported that SIRT1 prevents cellular senescence in human fibroblast, and that SIRT1-induced inhibition of cellular senescence is due to enhanced hTERT gene expression. In this study, we investigate the molecular mechanisms behind SIRT1-induced potentiation of hTERT trans...

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Detalles Bibliográficos
Autores principales: Yamashita, Shuntaro, Ogawa, Kaori, Ikei, Takahiro, Fujiki, Tsukasa, Katakura, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085005/
https://www.ncbi.nlm.nih.gov/pubmed/25000517
http://dx.doi.org/10.1371/journal.pone.0101864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085005/
https://www.ncbi.nlm.nih.gov/pubmed/25000517
http://dx.doi.org/10.1371/journal.pone.0101864

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