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Bilateral Carotid Paraganglioma: Surgery and Radiotherapy
BACKGROUND: Paragangliomas are relatively rare vascular tumors that develop from the neural crest cells of carotid bifurcation. They usually present as slow-growing, painless unilateral neck masses; bilateral presentation is rare and is mostly associated with familial forms. Bilateral total resectio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085101/ https://www.ncbi.nlm.nih.gov/pubmed/25057243 http://dx.doi.org/10.4137/CCRep.S14223 |
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author | Kiziltan, Huriye S Ozucer, Berke Eris, Ali H Veyseller, Bayram |
author_facet | Kiziltan, Huriye S Ozucer, Berke Eris, Ali H Veyseller, Bayram |
author_sort | Kiziltan, Huriye S |
collection | PubMed |
description | BACKGROUND: Paragangliomas are relatively rare vascular tumors that develop from the neural crest cells of carotid bifurcation. They usually present as slow-growing, painless unilateral neck masses; bilateral presentation is rare and is mostly associated with familial forms. Bilateral total resection is not always possible for high-grade bilateral tumors, and radiotherapy is a good alternative, with cure rates similar to surgery. CASE REPORT: A 35-year-old female patient was admitted with a chief complaint of a bilateral, painless mass located on her neck. Subsequent magnetic resonance imaging (MRI) and angiographic imaging revealed bilateral hypervascular masses surrounding her carotid at 360°, and they were interpreted as stage 3 carotid paragangliomas according to the Shamblin classification protocol. Surgery was carried out on the left carotid paraganglioma and the mass was totally resected. It was thought that the patient could not tolerate bilateral surgery. Primary radiotherapy was planned on the right carotid paraganglioma: 59.8 gray (Gy) conformal, Linac-based multileaf collimator radiotherapy with a 180 cGy daily dosage, and five fractions per week were planned. RESULTS: Follow-up at 3 months following the conclusion of radiotherapy revealed no significant regression. A follow-up MRI 6 months and 24 months later revealed 59% regression. Grade 2 esophagitis and minimal neck edema were the only complications noted during the course of radiotherapy and during the 24-month follow-up period. No complications or relapse were observed except for edema following neck surgery. |
format | Online Article Text |
id | pubmed-4085101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-40851012014-07-23 Bilateral Carotid Paraganglioma: Surgery and Radiotherapy Kiziltan, Huriye S Ozucer, Berke Eris, Ali H Veyseller, Bayram Clin Med Insights Case Rep Case Report BACKGROUND: Paragangliomas are relatively rare vascular tumors that develop from the neural crest cells of carotid bifurcation. They usually present as slow-growing, painless unilateral neck masses; bilateral presentation is rare and is mostly associated with familial forms. Bilateral total resection is not always possible for high-grade bilateral tumors, and radiotherapy is a good alternative, with cure rates similar to surgery. CASE REPORT: A 35-year-old female patient was admitted with a chief complaint of a bilateral, painless mass located on her neck. Subsequent magnetic resonance imaging (MRI) and angiographic imaging revealed bilateral hypervascular masses surrounding her carotid at 360°, and they were interpreted as stage 3 carotid paragangliomas according to the Shamblin classification protocol. Surgery was carried out on the left carotid paraganglioma and the mass was totally resected. It was thought that the patient could not tolerate bilateral surgery. Primary radiotherapy was planned on the right carotid paraganglioma: 59.8 gray (Gy) conformal, Linac-based multileaf collimator radiotherapy with a 180 cGy daily dosage, and five fractions per week were planned. RESULTS: Follow-up at 3 months following the conclusion of radiotherapy revealed no significant regression. A follow-up MRI 6 months and 24 months later revealed 59% regression. Grade 2 esophagitis and minimal neck edema were the only complications noted during the course of radiotherapy and during the 24-month follow-up period. No complications or relapse were observed except for edema following neck surgery. Libertas Academica 2014-07-03 /pmc/articles/PMC4085101/ /pubmed/25057243 http://dx.doi.org/10.4137/CCRep.S14223 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Case Report Kiziltan, Huriye S Ozucer, Berke Eris, Ali H Veyseller, Bayram Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title | Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title_full | Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title_fullStr | Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title_full_unstemmed | Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title_short | Bilateral Carotid Paraganglioma: Surgery and Radiotherapy |
title_sort | bilateral carotid paraganglioma: surgery and radiotherapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085101/ https://www.ncbi.nlm.nih.gov/pubmed/25057243 http://dx.doi.org/10.4137/CCRep.S14223 |
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