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Integrative Genomic Analysis for the Discovery of Biomarkers in Prostate Cancer

Genome-wide association studies (GWAS) have achieved great success in identifying single nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with risk of developing prostate cancer. However, GWAS do not typically link the genetic variants to the disease state or info...

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Detalles Bibliográficos
Autores principales: Hicks, Chindo, Koganti, Tejaswi, Giri, Shankar, Tekere, Memory, Ramani, Ritika, Sitthi-Amorn, Jitsuda, Vijayakumar, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085106/
https://www.ncbi.nlm.nih.gov/pubmed/25057237
http://dx.doi.org/10.4137/BMI.S13729
Descripción
Sumario:Genome-wide association studies (GWAS) have achieved great success in identifying single nucleotide polymorphisms (SNPs, herein called genetic variants) and genes associated with risk of developing prostate cancer. However, GWAS do not typically link the genetic variants to the disease state or inform the broader context in which the genetic variants operate. Here, we present a novel integrative genomics approach that combines GWAS information with gene expression data to infer the causal association between gene expression and the disease and to identify the network states and biological pathways enriched for genetic variants. We identified gene regulatory networks and biological pathways enriched for genetic variants, including the prostate cancer, IGF-1, JAK2, androgen, and prolactin signaling pathways. The integration of GWAS information with gene expression data provides insights about the broader context in which genetic variants associated with an increased risk of developing prostate cancer operate.