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ROR1, an embryonic protein with an emerging role in cancer biology

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonin...

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Autores principales: Borcherding, Nicholas, Kusner, David, Liu, Guang-Hui, Zhang, Weizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085287/
https://www.ncbi.nlm.nih.gov/pubmed/24752542
http://dx.doi.org/10.1007/s13238-014-0059-7
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author Borcherding, Nicholas
Kusner, David
Liu, Guang-Hui
Zhang, Weizhou
author_facet Borcherding, Nicholas
Kusner, David
Liu, Guang-Hui
Zhang, Weizhou
author_sort Borcherding, Nicholas
collection PubMed
description Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.
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spelling pubmed-40852872014-07-18 ROR1, an embryonic protein with an emerging role in cancer biology Borcherding, Nicholas Kusner, David Liu, Guang-Hui Zhang, Weizhou Protein Cell Mini-Review Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy. Higher Education Press 2014-04-22 2014-07 /pmc/articles/PMC4085287/ /pubmed/24752542 http://dx.doi.org/10.1007/s13238-014-0059-7 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Mini-Review
Borcherding, Nicholas
Kusner, David
Liu, Guang-Hui
Zhang, Weizhou
ROR1, an embryonic protein with an emerging role in cancer biology
title ROR1, an embryonic protein with an emerging role in cancer biology
title_full ROR1, an embryonic protein with an emerging role in cancer biology
title_fullStr ROR1, an embryonic protein with an emerging role in cancer biology
title_full_unstemmed ROR1, an embryonic protein with an emerging role in cancer biology
title_short ROR1, an embryonic protein with an emerging role in cancer biology
title_sort ror1, an embryonic protein with an emerging role in cancer biology
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085287/
https://www.ncbi.nlm.nih.gov/pubmed/24752542
http://dx.doi.org/10.1007/s13238-014-0059-7
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