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Small molecules that inhibit Vif-induced degradation of APOBEC3G
BACKGROUND: HIV-1 Vif is essential for virus replication in natural target cells such as T cells and macrophages. Vif recruits a ubiquitin ligase to degrade restrictive APOBEC3 proteins. APOBEC3G is one of the most potent retroviral restriction factors targeted by Vif and, as such, the Vif-APOBEC3G...
Autores principales: | Matsui, Masashi, Shindo, Keisuke, Izumi, Taisuke, Io, Katsuhiro, Shinohara, Masanobu, Komano, Jun, Kobayashi, Masayuki, Kadowaki, Norimitsu, Harris, Reuben S, Takaori-Kondo, Akifumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085377/ https://www.ncbi.nlm.nih.gov/pubmed/24986077 http://dx.doi.org/10.1186/1743-422X-11-122 |
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