Cargando…

Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges

Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or i...

Descripción completa

Detalles Bibliográficos
Autores principales: Parikh, Ankit, Anand, Utkarshini, Ugwu, Malachy C., Feridooni, Tiam, Massoud, Emad, Agu, Remigius U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085598/
https://www.ncbi.nlm.nih.gov/pubmed/24871904
http://dx.doi.org/10.3390/pharmaceutics6020249
_version_ 1782324685831143424
author Parikh, Ankit
Anand, Utkarshini
Ugwu, Malachy C.
Feridooni, Tiam
Massoud, Emad
Agu, Remigius U.
author_facet Parikh, Ankit
Anand, Utkarshini
Ugwu, Malachy C.
Feridooni, Tiam
Massoud, Emad
Agu, Remigius U.
author_sort Parikh, Ankit
collection PubMed
description Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested as reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates for nasal implants, formulation methods/optimization and characterization methods. Clinical applications and important considerations were also addressed. Clinically-approved implants (Propel™ implant, the Relieva stratus™ MicroFlow spacer, and the Sinu-Foam™ spacer) for CRS treatment was an important focus. The advantages and limitations, as well as future considerations, challenges and the need for additional research in the field of nasal drug implant development, were discussed.
format Online
Article
Text
id pubmed-4085598
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40855982014-07-09 Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges Parikh, Ankit Anand, Utkarshini Ugwu, Malachy C. Feridooni, Tiam Massoud, Emad Agu, Remigius U. Pharmaceutics Review Chronic inflammation and infection of the nasal sinuses, also referred to as Chronic Rhinosinusitis (CRS), severely affects patients’ quality of life. Adhesions, ostial stenosis, infection and inflammation relapses complicate chronic sinusitis treatment strategies. Drug-eluting stents, packings or implants have been suggested as reasonable alternatives for addressing these concerns. This article reviewed potential drug candidates for nasal implants, formulation methods/optimization and characterization methods. Clinical applications and important considerations were also addressed. Clinically-approved implants (Propel™ implant, the Relieva stratus™ MicroFlow spacer, and the Sinu-Foam™ spacer) for CRS treatment was an important focus. The advantages and limitations, as well as future considerations, challenges and the need for additional research in the field of nasal drug implant development, were discussed. MDPI 2014-05-27 /pmc/articles/PMC4085598/ /pubmed/24871904 http://dx.doi.org/10.3390/pharmaceutics6020249 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Parikh, Ankit
Anand, Utkarshini
Ugwu, Malachy C.
Feridooni, Tiam
Massoud, Emad
Agu, Remigius U.
Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title_full Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title_fullStr Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title_full_unstemmed Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title_short Drug-Eluting Nasal Implants: Formulation, Characterization, Clinical Applications and Challenges
title_sort drug-eluting nasal implants: formulation, characterization, clinical applications and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085598/
https://www.ncbi.nlm.nih.gov/pubmed/24871904
http://dx.doi.org/10.3390/pharmaceutics6020249
work_keys_str_mv AT parikhankit drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges
AT anandutkarshini drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges
AT ugwumalachyc drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges
AT feridoonitiam drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges
AT massoudemad drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges
AT aguremigiusu drugelutingnasalimplantsformulationcharacterizationclinicalapplicationsandchallenges