MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score

Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic reson...

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Autores principales: Haimerl, Michael, Verloh, Niklas, Fellner, Claudia, Zeman, Florian, Teufel, Andreas, Feigl, Stefan Fichtner-, Schreyer, Andreas G., Stroszczynski, Christian, Wiggermann, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085628/
https://www.ncbi.nlm.nih.gov/pubmed/25001391
http://dx.doi.org/10.1038/srep05621
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author Haimerl, Michael
Verloh, Niklas
Fellner, Claudia
Zeman, Florian
Teufel, Andreas
Feigl, Stefan Fichtner-
Schreyer, Andreas G.
Stroszczynski, Christian
Wiggermann, Philipp
author_facet Haimerl, Michael
Verloh, Niklas
Fellner, Claudia
Zeman, Florian
Teufel, Andreas
Feigl, Stefan Fichtner-
Schreyer, Andreas G.
Stroszczynski, Christian
Wiggermann, Philipp
author_sort Haimerl, Michael
collection PubMed
description Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.
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spelling pubmed-40856282014-07-09 MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score Haimerl, Michael Verloh, Niklas Fellner, Claudia Zeman, Florian Teufel, Andreas Feigl, Stefan Fichtner- Schreyer, Andreas G. Stroszczynski, Christian Wiggermann, Philipp Sci Rep Article Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function. Nature Publishing Group 2014-07-08 /pmc/articles/PMC4085628/ /pubmed/25001391 http://dx.doi.org/10.1038/srep05621 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Haimerl, Michael
Verloh, Niklas
Fellner, Claudia
Zeman, Florian
Teufel, Andreas
Feigl, Stefan Fichtner-
Schreyer, Andreas G.
Stroszczynski, Christian
Wiggermann, Philipp
MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title_full MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title_fullStr MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title_full_unstemmed MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title_short MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score
title_sort mri-based estimation of liver function: gd-eob-dtpa-enhanced t1 relaxometry of 3t vs. the meld score
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085628/
https://www.ncbi.nlm.nih.gov/pubmed/25001391
http://dx.doi.org/10.1038/srep05621
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