Convergent cortical innervation of striatal projection neurons

Anatomical studies have led to the assertion that intratelencephalic (IT) and pyramidal tract (PT) cortical neurons innervate different striatal projection neurons. To test this hypothesis, the responses of mouse striatal neurons to optogenetic activation of IT and PT axons were measured. Contrary t...

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Autores principales: Kress, Geraldine J., Yamawaki, Naoki, Wokosin, David L., Wickersham, Ian R., Shepherd, Gordon M.G., Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085670/
https://www.ncbi.nlm.nih.gov/pubmed/23666180
http://dx.doi.org/10.1038/nn.3397
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author Kress, Geraldine J.
Yamawaki, Naoki
Wokosin, David L.
Wickersham, Ian R.
Shepherd, Gordon M.G.
Surmeier, D. James
author_facet Kress, Geraldine J.
Yamawaki, Naoki
Wokosin, David L.
Wickersham, Ian R.
Shepherd, Gordon M.G.
Surmeier, D. James
author_sort Kress, Geraldine J.
collection PubMed
description Anatomical studies have led to the assertion that intratelencephalic (IT) and pyramidal tract (PT) cortical neurons innervate different striatal projection neurons. To test this hypothesis, the responses of mouse striatal neurons to optogenetic activation of IT and PT axons were measured. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons (SPNs) responded to both IT and PT activation, arguing that these cortical networks innervate both striatal projection neurons.
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spelling pubmed-40856702014-07-08 Convergent cortical innervation of striatal projection neurons Kress, Geraldine J. Yamawaki, Naoki Wokosin, David L. Wickersham, Ian R. Shepherd, Gordon M.G. Surmeier, D. James Nat Neurosci Article Anatomical studies have led to the assertion that intratelencephalic (IT) and pyramidal tract (PT) cortical neurons innervate different striatal projection neurons. To test this hypothesis, the responses of mouse striatal neurons to optogenetic activation of IT and PT axons were measured. Contrary to expectation, direct and indirect pathway striatal spiny projection neurons (SPNs) responded to both IT and PT activation, arguing that these cortical networks innervate both striatal projection neurons. 2013-05-12 2013-06 /pmc/articles/PMC4085670/ /pubmed/23666180 http://dx.doi.org/10.1038/nn.3397 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kress, Geraldine J.
Yamawaki, Naoki
Wokosin, David L.
Wickersham, Ian R.
Shepherd, Gordon M.G.
Surmeier, D. James
Convergent cortical innervation of striatal projection neurons
title Convergent cortical innervation of striatal projection neurons
title_full Convergent cortical innervation of striatal projection neurons
title_fullStr Convergent cortical innervation of striatal projection neurons
title_full_unstemmed Convergent cortical innervation of striatal projection neurons
title_short Convergent cortical innervation of striatal projection neurons
title_sort convergent cortical innervation of striatal projection neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085670/
https://www.ncbi.nlm.nih.gov/pubmed/23666180
http://dx.doi.org/10.1038/nn.3397
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