Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line

BACKGROUND: Mutations in NBN, the gene for Nijmegen Breakage Syndrome (NBS), are thought to predispose women to developing breast cancer, but a breast cancer cell line containing mutations in NBN has not yet been described. The p.R215W missense mutation occurs at sub-polymorphic frequencies in sever...

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Detalles Bibliográficos
Autores principales: Schröder-Heurich, Bianca, Bogdanova, Natalia, Wieland, Britta, Xie, Xiaoxi, Noskowicz, Monika, Park-Simon, Tjoung-Won, Hillemanns, Peter, Christiansen, Hans, Dörk, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085727/
https://www.ncbi.nlm.nih.gov/pubmed/24928521
http://dx.doi.org/10.1186/1471-2407-14-434

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