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RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME

In the absence of intervention, the rate of vertical transmission of HIV can range from 15-45%. With the inclusion of antiretroviral drugs during pregnancy and the choice of delivery route this amounts to less than 2%. However ARV use during pregnancy has generated several questions regarding the ad...

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Autores principales: Barral, Maria F.M., de Oliveira, Gisele R., Lobato, Rubens C., Mendoza-Sassi, Raul A., Martínez, Ana M.b., Gonçalves, Carla V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085844/
https://www.ncbi.nlm.nih.gov/pubmed/24626415
http://dx.doi.org/10.1590/S0036-46652014000200008
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author Barral, Maria F.M.
de Oliveira, Gisele R.
Lobato, Rubens C.
Mendoza-Sassi, Raul A.
Martínez, Ana M.b.
Gonçalves, Carla V.
author_facet Barral, Maria F.M.
de Oliveira, Gisele R.
Lobato, Rubens C.
Mendoza-Sassi, Raul A.
Martínez, Ana M.b.
Gonçalves, Carla V.
author_sort Barral, Maria F.M.
collection PubMed
description In the absence of intervention, the rate of vertical transmission of HIV can range from 15-45%. With the inclusion of antiretroviral drugs during pregnancy and the choice of delivery route this amounts to less than 2%. However ARV use during pregnancy has generated several questions regarding the adverse effects of the gestational and neonatal outcome. This study aims to analyze the risk factors for vertical transmission of HIV-1 seropositive pregnant women living in Rio Grande and the influence of the use of ARVs in pregnancy outcome. Among the 262 pregnant women studied the rate of vertical transmission of HIV was found to be 3.8%. Regarding the VT, there was a lower risk of transmission when antiretroviral drugs were used and prenatal care was conducted at the referral service. However, the use of ART did not influence the outcome of pregnancy. However, initiation of prenatal care after the first trimester had an influence on low birth weight, as well as performance of less than six visits increased the risk of prematurity. Therefore, the risk factors analyzed in this study appear to be related to the realization of inadequate pre-natal and maternal behavior.
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spelling pubmed-40858442014-07-16 RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME Barral, Maria F.M. de Oliveira, Gisele R. Lobato, Rubens C. Mendoza-Sassi, Raul A. Martínez, Ana M.b. Gonçalves, Carla V. Rev Inst Med Trop Sao Paulo HIV/AIDS In the absence of intervention, the rate of vertical transmission of HIV can range from 15-45%. With the inclusion of antiretroviral drugs during pregnancy and the choice of delivery route this amounts to less than 2%. However ARV use during pregnancy has generated several questions regarding the adverse effects of the gestational and neonatal outcome. This study aims to analyze the risk factors for vertical transmission of HIV-1 seropositive pregnant women living in Rio Grande and the influence of the use of ARVs in pregnancy outcome. Among the 262 pregnant women studied the rate of vertical transmission of HIV was found to be 3.8%. Regarding the VT, there was a lower risk of transmission when antiretroviral drugs were used and prenatal care was conducted at the referral service. However, the use of ART did not influence the outcome of pregnancy. However, initiation of prenatal care after the first trimester had an influence on low birth weight, as well as performance of less than six visits increased the risk of prematurity. Therefore, the risk factors analyzed in this study appear to be related to the realization of inadequate pre-natal and maternal behavior. Instituto de Medicina Tropical 2014 /pmc/articles/PMC4085844/ /pubmed/24626415 http://dx.doi.org/10.1590/S0036-46652014000200008 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle HIV/AIDS
Barral, Maria F.M.
de Oliveira, Gisele R.
Lobato, Rubens C.
Mendoza-Sassi, Raul A.
Martínez, Ana M.b.
Gonçalves, Carla V.
RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title_full RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title_fullStr RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title_full_unstemmed RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title_short RISK FACTORS OF HIV-1 VERTICAL TRANSMISSION (VT) AND THE INFLUENCE OF ANTIRETROVIRAL THERAPY (ART) IN PREGNANCY OUTCOME
title_sort risk factors of hiv-1 vertical transmission (vt) and the influence of antiretroviral therapy (art) in pregnancy outcome
topic HIV/AIDS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085844/
https://www.ncbi.nlm.nih.gov/pubmed/24626415
http://dx.doi.org/10.1590/S0036-46652014000200008
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