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THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT

Background: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. Metho...

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Autores principales: Nunes, Cynara Carvalho, Matte, Maria Cristina Cotta, Dias, Claudia Fontoura, Araújo, Leonardo Augusto Luvison, Guimarães, Luciano Santos Pinto, Almeida, Sabrina, Brígido, Luis Fernando Macedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2014
Materias:
HIV
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085862/
https://www.ncbi.nlm.nih.gov/pubmed/24878998
http://dx.doi.org/10.1590/S0036-46652014000300005
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author Nunes, Cynara Carvalho
Matte, Maria Cristina Cotta
Dias, Claudia Fontoura
Araújo, Leonardo Augusto Luvison
Guimarães, Luciano Santos Pinto
Almeida, Sabrina
Brígido, Luis Fernando Macedo
author_facet Nunes, Cynara Carvalho
Matte, Maria Cristina Cotta
Dias, Claudia Fontoura
Araújo, Leonardo Augusto Luvison
Guimarães, Luciano Santos Pinto
Almeida, Sabrina
Brígido, Luis Fernando Macedo
author_sort Nunes, Cynara Carvalho
collection PubMed
description Background: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. Methods: From July/2004 to December/2005, 135 HIV-infected patients were recruited. The partial pol region was subtyped by phylogeny. A generalized estimating equation (GEE) model was used to examine the relationship between viral subtype, CD4+ T cell count and viral load levels before antiretroviral therapy. Hazard ratio (Cox regression) was used to evaluate factors associated with viral suppression (viral load < 50 copies/mL at six months). Results: Main HIV-1 subtypes included B (29.4%), C (28.2%), and CRF31_BC (23.5%). Subtypes B and C showed a similar trend in CD4+ T cell decline. Comparison of non-B (C and CRF31_BC) and B subtypes revealed no significant difference in the proportion of patients with viral suppression at six months (week 24). Higher CD4+ T cell count and lower viral load were independently associated with viral suppression. Conclusion: No significant differences were found between subtypes; however, lower viral load and higher CD4+ T cell count before therapy were associated with better response.
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spelling pubmed-40858622014-07-16 THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT Nunes, Cynara Carvalho Matte, Maria Cristina Cotta Dias, Claudia Fontoura Araújo, Leonardo Augusto Luvison Guimarães, Luciano Santos Pinto Almeida, Sabrina Brígido, Luis Fernando Macedo Rev Inst Med Trop Sao Paulo HIV Background: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. Methods: From July/2004 to December/2005, 135 HIV-infected patients were recruited. The partial pol region was subtyped by phylogeny. A generalized estimating equation (GEE) model was used to examine the relationship between viral subtype, CD4+ T cell count and viral load levels before antiretroviral therapy. Hazard ratio (Cox regression) was used to evaluate factors associated with viral suppression (viral load < 50 copies/mL at six months). Results: Main HIV-1 subtypes included B (29.4%), C (28.2%), and CRF31_BC (23.5%). Subtypes B and C showed a similar trend in CD4+ T cell decline. Comparison of non-B (C and CRF31_BC) and B subtypes revealed no significant difference in the proportion of patients with viral suppression at six months (week 24). Higher CD4+ T cell count and lower viral load were independently associated with viral suppression. Conclusion: No significant differences were found between subtypes; however, lower viral load and higher CD4+ T cell count before therapy were associated with better response. Instituto de Medicina Tropical 2014 /pmc/articles/PMC4085862/ /pubmed/24878998 http://dx.doi.org/10.1590/S0036-46652014000300005 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle HIV
Nunes, Cynara Carvalho
Matte, Maria Cristina Cotta
Dias, Claudia Fontoura
Araújo, Leonardo Augusto Luvison
Guimarães, Luciano Santos Pinto
Almeida, Sabrina
Brígido, Luis Fernando Macedo
THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title_full THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title_fullStr THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title_full_unstemmed THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title_short THE INFLUENCE OF HIV-1 SUBTYPES C, CRF31_BC AND B ON DISEASE PROGRESSION AND INITIAL VIROLOGIC RESPONSE TO HAART IN A SOUTHERN BRAZILIAN COHORT
title_sort influence of hiv-1 subtypes c, crf31_bc and b on disease progression and initial virologic response to haart in a southern brazilian cohort
topic HIV
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085862/
https://www.ncbi.nlm.nih.gov/pubmed/24878998
http://dx.doi.org/10.1590/S0036-46652014000300005
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