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FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Instituto de Medicina Tropical
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085867/ https://www.ncbi.nlm.nih.gov/pubmed/24879007 http://dx.doi.org/10.1590/S0036-46652014000300014 |
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author | Amâncio, Frederico Figueiredo Pereira, Maira Alves Iani, Felipe Campos de Melo D'anunciação, Lorena de Almeida, Jorge Luís Carvalho Soares, Janer Aparecida Silveira Ferraz, Marcela Lencine Vale, Thiago Cardoso Lambertucci, José Roberto Carneiro, Mariângela |
author_facet | Amâncio, Frederico Figueiredo Pereira, Maira Alves Iani, Felipe Campos de Melo D'anunciação, Lorena de Almeida, Jorge Luís Carvalho Soares, Janer Aparecida Silveira Ferraz, Marcela Lencine Vale, Thiago Cardoso Lambertucci, José Roberto Carneiro, Mariângela |
author_sort | Amâncio, Frederico Figueiredo |
collection | PubMed |
description | Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazonas and Pará, followed by Rio de Janeiro and São Paulo. In Minas Gerais, the first confirmed case of DENV-4 occurred in the municipality of Frutal in 2011 and has now been isolated from a growing number of patients. Although DENV-2 is associated with the highest risk of severe forms of the disease and death due to the infection, DENV-4 has also been associated with severe forms of the disease and an increasing risk of hemorrhagic manifestations. Herein, the first fatal case of confirmed DENV-4 in Brazil is reported. The patient was an 11-year-old girl from the municipality of Montes Claros in northern Minas Gerais State, Brazil. She had idiopathic thrombocytopenic purpura as a comorbid condition and presented with a fulminant course of infection, leading to death due to hemorrhagic complications. Diagnosis was confirmed by detection of Dengue-specific antibodies using IgM capture enzyme-linked immunosorbent assay and semi-nested RT-PCR. Primary care physicians and other health-care providers should bear in mind that DENV-4 can also result in severe forms of the disease and lead to hemorrhagic complications and death, mainly when dengue infection is associated with coexisting conditions. |
format | Online Article Text |
id | pubmed-4085867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Instituto de Medicina Tropical |
record_format | MEDLINE/PubMed |
spelling | pubmed-40858672014-07-16 FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL Amâncio, Frederico Figueiredo Pereira, Maira Alves Iani, Felipe Campos de Melo D'anunciação, Lorena de Almeida, Jorge Luís Carvalho Soares, Janer Aparecida Silveira Ferraz, Marcela Lencine Vale, Thiago Cardoso Lambertucci, José Roberto Carneiro, Mariângela Rev Inst Med Trop Sao Paulo Case Report Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazonas and Pará, followed by Rio de Janeiro and São Paulo. In Minas Gerais, the first confirmed case of DENV-4 occurred in the municipality of Frutal in 2011 and has now been isolated from a growing number of patients. Although DENV-2 is associated with the highest risk of severe forms of the disease and death due to the infection, DENV-4 has also been associated with severe forms of the disease and an increasing risk of hemorrhagic manifestations. Herein, the first fatal case of confirmed DENV-4 in Brazil is reported. The patient was an 11-year-old girl from the municipality of Montes Claros in northern Minas Gerais State, Brazil. She had idiopathic thrombocytopenic purpura as a comorbid condition and presented with a fulminant course of infection, leading to death due to hemorrhagic complications. Diagnosis was confirmed by detection of Dengue-specific antibodies using IgM capture enzyme-linked immunosorbent assay and semi-nested RT-PCR. Primary care physicians and other health-care providers should bear in mind that DENV-4 can also result in severe forms of the disease and lead to hemorrhagic complications and death, mainly when dengue infection is associated with coexisting conditions. Instituto de Medicina Tropical 2014 /pmc/articles/PMC4085867/ /pubmed/24879007 http://dx.doi.org/10.1590/S0036-46652014000300014 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Amâncio, Frederico Figueiredo Pereira, Maira Alves Iani, Felipe Campos de Melo D'anunciação, Lorena de Almeida, Jorge Luís Carvalho Soares, Janer Aparecida Silveira Ferraz, Marcela Lencine Vale, Thiago Cardoso Lambertucci, José Roberto Carneiro, Mariângela FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL |
title | FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC
PURPURA AS A COMORBID CONDITION IN BRAZIL |
title_full | FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC
PURPURA AS A COMORBID CONDITION IN BRAZIL |
title_fullStr | FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC
PURPURA AS A COMORBID CONDITION IN BRAZIL |
title_full_unstemmed | FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC
PURPURA AS A COMORBID CONDITION IN BRAZIL |
title_short | FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC
PURPURA AS A COMORBID CONDITION IN BRAZIL |
title_sort | fatal outcome of infection by dengue 4 in a patient with thrombocytopenic
purpura as a comorbid condition in brazil |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085867/ https://www.ncbi.nlm.nih.gov/pubmed/24879007 http://dx.doi.org/10.1590/S0036-46652014000300014 |
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