Cargando…

FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL

Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazo...

Descripción completa

Detalles Bibliográficos
Autores principales: Amâncio, Frederico Figueiredo, Pereira, Maira Alves, Iani, Felipe Campos de Melo, D'anunciação, Lorena, de Almeida, Jorge Luís Carvalho, Soares, Janer Aparecida Silveira, Ferraz, Marcela Lencine, Vale, Thiago Cardoso, Lambertucci, José Roberto, Carneiro, Mariângela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085867/
https://www.ncbi.nlm.nih.gov/pubmed/24879007
http://dx.doi.org/10.1590/S0036-46652014000300014
_version_ 1782324721341169664
author Amâncio, Frederico Figueiredo
Pereira, Maira Alves
Iani, Felipe Campos de Melo
D'anunciação, Lorena
de Almeida, Jorge Luís Carvalho
Soares, Janer Aparecida Silveira
Ferraz, Marcela Lencine
Vale, Thiago Cardoso
Lambertucci, José Roberto
Carneiro, Mariângela
author_facet Amâncio, Frederico Figueiredo
Pereira, Maira Alves
Iani, Felipe Campos de Melo
D'anunciação, Lorena
de Almeida, Jorge Luís Carvalho
Soares, Janer Aparecida Silveira
Ferraz, Marcela Lencine
Vale, Thiago Cardoso
Lambertucci, José Roberto
Carneiro, Mariângela
author_sort Amâncio, Frederico Figueiredo
collection PubMed
description Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazonas and Pará, followed by Rio de Janeiro and São Paulo. In Minas Gerais, the first confirmed case of DENV-4 occurred in the municipality of Frutal in 2011 and has now been isolated from a growing number of patients. Although DENV-2 is associated with the highest risk of severe forms of the disease and death due to the infection, DENV-4 has also been associated with severe forms of the disease and an increasing risk of hemorrhagic manifestations. Herein, the first fatal case of confirmed DENV-4 in Brazil is reported. The patient was an 11-year-old girl from the municipality of Montes Claros in northern Minas Gerais State, Brazil. She had idiopathic thrombocytopenic purpura as a comorbid condition and presented with a fulminant course of infection, leading to death due to hemorrhagic complications. Diagnosis was confirmed by detection of Dengue-specific antibodies using IgM capture enzyme-linked immunosorbent assay and semi-nested RT-PCR. Primary care physicians and other health-care providers should bear in mind that DENV-4 can also result in severe forms of the disease and lead to hemorrhagic complications and death, mainly when dengue infection is associated with coexisting conditions.
format Online
Article
Text
id pubmed-4085867
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Instituto de Medicina Tropical
record_format MEDLINE/PubMed
spelling pubmed-40858672014-07-16 FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL Amâncio, Frederico Figueiredo Pereira, Maira Alves Iani, Felipe Campos de Melo D'anunciação, Lorena de Almeida, Jorge Luís Carvalho Soares, Janer Aparecida Silveira Ferraz, Marcela Lencine Vale, Thiago Cardoso Lambertucci, José Roberto Carneiro, Mariângela Rev Inst Med Trop Sao Paulo Case Report Dengue is currently a major public-health problem. Dengue virus (DENV) is classified into four distinct serotypes, DENV 1-4. After 28 years of absence, DENV-4 was again detected in Brazil in 2010 in Roraima State, and one year later, the virus was identified in the northern Brazilian states of Amazonas and Pará, followed by Rio de Janeiro and São Paulo. In Minas Gerais, the first confirmed case of DENV-4 occurred in the municipality of Frutal in 2011 and has now been isolated from a growing number of patients. Although DENV-2 is associated with the highest risk of severe forms of the disease and death due to the infection, DENV-4 has also been associated with severe forms of the disease and an increasing risk of hemorrhagic manifestations. Herein, the first fatal case of confirmed DENV-4 in Brazil is reported. The patient was an 11-year-old girl from the municipality of Montes Claros in northern Minas Gerais State, Brazil. She had idiopathic thrombocytopenic purpura as a comorbid condition and presented with a fulminant course of infection, leading to death due to hemorrhagic complications. Diagnosis was confirmed by detection of Dengue-specific antibodies using IgM capture enzyme-linked immunosorbent assay and semi-nested RT-PCR. Primary care physicians and other health-care providers should bear in mind that DENV-4 can also result in severe forms of the disease and lead to hemorrhagic complications and death, mainly when dengue infection is associated with coexisting conditions. Instituto de Medicina Tropical 2014 /pmc/articles/PMC4085867/ /pubmed/24879007 http://dx.doi.org/10.1590/S0036-46652014000300014 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Amâncio, Frederico Figueiredo
Pereira, Maira Alves
Iani, Felipe Campos de Melo
D'anunciação, Lorena
de Almeida, Jorge Luís Carvalho
Soares, Janer Aparecida Silveira
Ferraz, Marcela Lencine
Vale, Thiago Cardoso
Lambertucci, José Roberto
Carneiro, Mariângela
FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title_full FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title_fullStr FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title_full_unstemmed FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title_short FATAL OUTCOME OF INFECTION BY DENGUE 4 IN A PATIENT WITH THROMBOCYTOPENIC PURPURA AS A COMORBID CONDITION IN BRAZIL
title_sort fatal outcome of infection by dengue 4 in a patient with thrombocytopenic purpura as a comorbid condition in brazil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085867/
https://www.ncbi.nlm.nih.gov/pubmed/24879007
http://dx.doi.org/10.1590/S0036-46652014000300014
work_keys_str_mv AT amanciofredericofigueiredo fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT pereiramairaalves fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT ianifelipecamposdemelo fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT danunciacaolorena fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT dealmeidajorgeluiscarvalho fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT soaresjaneraparecidasilveira fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT ferrazmarcelalencine fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT valethiagocardoso fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT lambertuccijoseroberto fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil
AT carneiromariangela fataloutcomeofinfectionbydengue4inapatientwiththrombocytopenicpurpuraasacomorbidconditioninbrazil