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Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study

Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month period, all patients at the Leuven Institute of Fertility and Embryology (LIFE) were randomly allocated t...

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Autores principales: Campo, R., Binda, M.M., Van Kerkhoven, G., Frederickx, V., Serneels, A., Roziers, P., Lopes, A.S., Gordts, S., Puttemans, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universa Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086013/
https://www.ncbi.nlm.nih.gov/pubmed/25009716
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author Campo, R.
Binda, M.M.
Van Kerkhoven, G.
Frederickx, V.
Serneels, A.
Roziers, P.
Lopes, A.S.
Gordts, S.
Puttemans, P.
Gordts, S.
author_facet Campo, R.
Binda, M.M.
Van Kerkhoven, G.
Frederickx, V.
Serneels, A.
Roziers, P.
Lopes, A.S.
Gordts, S.
Puttemans, P.
Gordts, S.
author_sort Campo, R.
collection PubMed
description Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month period, all patients at the Leuven Institute of Fertility and Embryology (LIFE) were randomly allocated to have their embryos cultured in either the standard sequential culture medium ISM1 (control) or in a new universal medium (GM501) (study group). Primary outcome parameters were clinical pregnancy and live birth rate. The secondary outcome parameter was the correlation of embryo fragmentation rate with pregnancy outcome. Results: We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies born. The number of embryos with a minimal fragmentation rate (less than 30%) was significantly higher in the GM501 study group. Conclusion: Although a significant higher embryo fragmentation rate was seen in In vitro culture of embryos in GM501, pregnancy outcome results were comparable to those of embryos cultured in ISM1. According to our results the value of embryo morphological criteria as a parameter for pregnancy outcome should be examined and discussed again.
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spelling pubmed-40860132014-07-09 Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study Campo, R. Binda, M.M. Van Kerkhoven, G. Frederickx, V. Serneels, A. Roziers, P. Lopes, A.S. Gordts, S. Puttemans, P. Gordts, S. Facts Views Vis Obgyn Original Paper Aim of the study: Pilot study to analyse the efficacy and embryo morphology using a new human embryo culture medium (GM501) versus the conventional used medium (ISM1). Methods: Over a four-month period, all patients at the Leuven Institute of Fertility and Embryology (LIFE) were randomly allocated to have their embryos cultured in either the standard sequential culture medium ISM1 (control) or in a new universal medium (GM501) (study group). Primary outcome parameters were clinical pregnancy and live birth rate. The secondary outcome parameter was the correlation of embryo fragmentation rate with pregnancy outcome. Results: We did not observe any differences between the ISM1 control group and GM501 study group with regard to fertilization, pregnancy, implantation rates, ongoing pregnancy, and babies born. The number of embryos with a minimal fragmentation rate (less than 30%) was significantly higher in the GM501 study group. Conclusion: Although a significant higher embryo fragmentation rate was seen in In vitro culture of embryos in GM501, pregnancy outcome results were comparable to those of embryos cultured in ISM1. According to our results the value of embryo morphological criteria as a parameter for pregnancy outcome should be examined and discussed again. Universa Press 2010 /pmc/articles/PMC4086013/ /pubmed/25009716 Text en Copyright: © 2010 Facts, Views & Vision http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Campo, R.
Binda, M.M.
Van Kerkhoven, G.
Frederickx, V.
Serneels, A.
Roziers, P.
Lopes, A.S.
Gordts, S.
Puttemans, P.
Gordts, S.
Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title_full Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title_fullStr Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title_full_unstemmed Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title_short Critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
title_sort critical reappraisal of embryo quality as a predictive parameter for pregnancy outcome: a pilot study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086013/
https://www.ncbi.nlm.nih.gov/pubmed/25009716
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