SARA-Coffee web server, a tool for the computation of RNA sequence and structure multiple alignments

This article introduces the SARA-Coffee web server; a service allowing the online computation of 3D structure based multiple RNA sequence alignments. The server makes it possible to combine sequences with and without known 3D structures. Given a set of sequences SARA-Coffee outputs a multiple sequen...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Tommaso, Paolo, Bussotti, Giovanni, Kemena, Carsten, Capriotti, Emidio, Chatzou, Maria, Prieto, Pablo, Notredame, Cedric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086076/
https://www.ncbi.nlm.nih.gov/pubmed/24972831
http://dx.doi.org/10.1093/nar/gku459
Descripción
Sumario:This article introduces the SARA-Coffee web server; a service allowing the online computation of 3D structure based multiple RNA sequence alignments. The server makes it possible to combine sequences with and without known 3D structures. Given a set of sequences SARA-Coffee outputs a multiple sequence alignment along with a reliability index for every sequence, column and aligned residue. SARA-Coffee combines SARA, a pairwise structural RNA aligner with the R-Coffee multiple RNA aligner in a way that has been shown to improve alignment accuracy over most sequence aligners when enough structural data is available. The server can be accessed from http://tcoffee.crg.cat/apps/tcoffee/do:saracoffee.

Ejemplares similares