ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites

The ProBiS-ligands web server predicts binding of ligands to a protein structure. Starting with a protein structure or binding site, ProBiS-ligands first identifies template proteins in the Protein Data Bank that share similar binding sites. Based on the superimpositions of the query protein and the...

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Detalles Bibliográficos
Autores principales: Konc, Janez, Janežič, Dušanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086080/
https://www.ncbi.nlm.nih.gov/pubmed/24861616
http://dx.doi.org/10.1093/nar/gku460
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author Konc, Janez
Janežič, Dušanka
author_facet Konc, Janez
Janežič, Dušanka
author_sort Konc, Janez
collection PubMed
description The ProBiS-ligands web server predicts binding of ligands to a protein structure. Starting with a protein structure or binding site, ProBiS-ligands first identifies template proteins in the Protein Data Bank that share similar binding sites. Based on the superimpositions of the query protein and the similar binding sites found, the server then transposes the ligand structures from those sites to the query protein. Such ligand prediction supports many activities, e.g. drug repurposing. The ProBiS-ligands web server, an extension of the ProBiS web server, is open and free to all users at http://probis.cmm.ki.si/ligands.
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spelling pubmed-40860802014-10-28 ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites Konc, Janez Janežič, Dušanka Nucleic Acids Res Article The ProBiS-ligands web server predicts binding of ligands to a protein structure. Starting with a protein structure or binding site, ProBiS-ligands first identifies template proteins in the Protein Data Bank that share similar binding sites. Based on the superimpositions of the query protein and the similar binding sites found, the server then transposes the ligand structures from those sites to the query protein. Such ligand prediction supports many activities, e.g. drug repurposing. The ProBiS-ligands web server, an extension of the ProBiS web server, is open and free to all users at http://probis.cmm.ki.si/ligands. Oxford University Press 2014-07-01 2014-05-26 /pmc/articles/PMC4086080/ /pubmed/24861616 http://dx.doi.org/10.1093/nar/gku460 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Konc, Janez
Janežič, Dušanka
ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title_full ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title_fullStr ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title_full_unstemmed ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title_short ProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites
title_sort probis-ligands: a web server for prediction of ligands by examination of protein binding sites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086080/
https://www.ncbi.nlm.nih.gov/pubmed/24861616
http://dx.doi.org/10.1093/nar/gku460
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