PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. G...

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Detalles Bibliográficos
Autores principales: Baspinar, Alper, Cukuroglu, Engin, Nussinov, Ruth, Keskin, Ozlem, Gursoy, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086120/
https://www.ncbi.nlm.nih.gov/pubmed/24829450
http://dx.doi.org/10.1093/nar/gku397
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author Baspinar, Alper
Cukuroglu, Engin
Nussinov, Ruth
Keskin, Ozlem
Gursoy, Attila
author_facet Baspinar, Alper
Cukuroglu, Engin
Nussinov, Ruth
Keskin, Ozlem
Gursoy, Attila
author_sort Baspinar, Alper
collection PubMed
description The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.
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spelling pubmed-40861202014-10-28 PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes Baspinar, Alper Cukuroglu, Engin Nussinov, Ruth Keskin, Ozlem Gursoy, Attila Nucleic Acids Res Article The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism. Oxford University Press 2014-07-01 2014-05-14 /pmc/articles/PMC4086120/ /pubmed/24829450 http://dx.doi.org/10.1093/nar/gku397 Text en © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Article
Baspinar, Alper
Cukuroglu, Engin
Nussinov, Ruth
Keskin, Ozlem
Gursoy, Attila
PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title_full PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title_fullStr PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title_full_unstemmed PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title_short PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes
title_sort prism: a web server and repository for prediction of protein–protein interactions and modeling their 3d complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086120/
https://www.ncbi.nlm.nih.gov/pubmed/24829450
http://dx.doi.org/10.1093/nar/gku397
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AT keskinozlem prismawebserverandrepositoryforpredictionofproteinproteininteractionsandmodelingtheir3dcomplexes
AT gursoyattila prismawebserverandrepositoryforpredictionofproteinproteininteractionsandmodelingtheir3dcomplexes

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