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Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)

For unresectable colorectal liver metastases (CRLM), hepatic resection with or without chemotherapy is the only curative treatment that sufficiently achieves long-term survival. However, occasional severe allergic responses to anticancer drugs necessitate treatment discontinuation. A 45-year-old wom...

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Autores principales: Komori, Hiroyuki, Beppu, Toru, Sakamoto, Yasuo, Miyamoto, Yuji, Hayashi, Hiromitsu, Imai, Katsunori, Nitta, Hidetoshi, Watanabe, Masayuki, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086249/
https://www.ncbi.nlm.nih.gov/pubmed/25031875
http://dx.doi.org/10.1155/2014/906759
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author Komori, Hiroyuki
Beppu, Toru
Sakamoto, Yasuo
Miyamoto, Yuji
Hayashi, Hiromitsu
Imai, Katsunori
Nitta, Hidetoshi
Watanabe, Masayuki
Baba, Hideo
author_facet Komori, Hiroyuki
Beppu, Toru
Sakamoto, Yasuo
Miyamoto, Yuji
Hayashi, Hiromitsu
Imai, Katsunori
Nitta, Hidetoshi
Watanabe, Masayuki
Baba, Hideo
author_sort Komori, Hiroyuki
collection PubMed
description For unresectable colorectal liver metastases (CRLM), hepatic resection with or without chemotherapy is the only curative treatment that sufficiently achieves long-term survival. However, occasional severe allergic responses to anticancer drugs necessitate treatment discontinuation. A 45-year-old woman presented with metachronous unresectable colorectal liver metastases. Chemotherapy with oxaliplatin plus 5-FU and leucovorin (FOLFOX) was initiated, but severe allergic dermatitis developed after the second cycle. Although she reported no prior history of adverse reactions to tegafur-uracil, a drug lymphocyte stimulation test showed an allergic response to 5-FU. We subsequently replaced with Irinotecan plus S-1 (IRIS) chemotherapy which was well tolerated and resulted in a partial response after 3 cycles. As a result, right trisectionectomy was successfully performed and no recurrence was detected in the following 3 years. A severe allergic reaction to intravenous 5-FU-containing drug regimens can be successfully alleviated by switching to S-1-containing regimens such as IRIS or S-1 plus oxaliplatin (SOX).
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spelling pubmed-40862492014-07-16 Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX) Komori, Hiroyuki Beppu, Toru Sakamoto, Yasuo Miyamoto, Yuji Hayashi, Hiromitsu Imai, Katsunori Nitta, Hidetoshi Watanabe, Masayuki Baba, Hideo Case Rep Gastrointest Med Case Report For unresectable colorectal liver metastases (CRLM), hepatic resection with or without chemotherapy is the only curative treatment that sufficiently achieves long-term survival. However, occasional severe allergic responses to anticancer drugs necessitate treatment discontinuation. A 45-year-old woman presented with metachronous unresectable colorectal liver metastases. Chemotherapy with oxaliplatin plus 5-FU and leucovorin (FOLFOX) was initiated, but severe allergic dermatitis developed after the second cycle. Although she reported no prior history of adverse reactions to tegafur-uracil, a drug lymphocyte stimulation test showed an allergic response to 5-FU. We subsequently replaced with Irinotecan plus S-1 (IRIS) chemotherapy which was well tolerated and resulted in a partial response after 3 cycles. As a result, right trisectionectomy was successfully performed and no recurrence was detected in the following 3 years. A severe allergic reaction to intravenous 5-FU-containing drug regimens can be successfully alleviated by switching to S-1-containing regimens such as IRIS or S-1 plus oxaliplatin (SOX). Hindawi Publishing Corporation 2014 2014-06-17 /pmc/articles/PMC4086249/ /pubmed/25031875 http://dx.doi.org/10.1155/2014/906759 Text en Copyright © 2014 Hiroyuki Komori et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Komori, Hiroyuki
Beppu, Toru
Sakamoto, Yasuo
Miyamoto, Yuji
Hayashi, Hiromitsu
Imai, Katsunori
Nitta, Hidetoshi
Watanabe, Masayuki
Baba, Hideo
Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title_full Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title_fullStr Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title_full_unstemmed Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title_short Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucovorin (FOLFOX)
title_sort irinotecan plus s-1 followed by hepatectomy for a patient with initially unresectable colorectal liver metastases, who showed severe drug rash with oxaliplatin plus 5-fu and leucovorin (folfox)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086249/
https://www.ncbi.nlm.nih.gov/pubmed/25031875
http://dx.doi.org/10.1155/2014/906759
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