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Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs. This feedback protects against cholesterol overaccumulation i...

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Detalles Bibliográficos
Autores principales:	Das, Akash, Brown, Michael S, Anderson, Donald D, Goldstein, Joseph L, Radhakrishnan, Arun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086274/ https://www.ncbi.nlm.nih.gov/pubmed/24920391 http://dx.doi.org/10.7554/eLife.02882

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