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Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device

Brain-computer interface (BCI) technology is being incorporated into new stroke rehabilitation devices, but little is known about brain changes associated with its use. We collected anatomical and functional MRI of nine stroke patients with persistent upper extremity motor impairment before, during,...

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Autores principales: Young, Brittany Mei, Nigogosyan, Zack, Remsik, Alexander, Walton, Léo M., Song, Jie, Nair, Veena A., Grogan, Scott W., Tyler, Mitchell E., Edwards, Dorothy Farrar, Caldera, Kristin, Sattin, Justin A., Williams, Justin C., Prabhakaran, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086321/
https://www.ncbi.nlm.nih.gov/pubmed/25071547
http://dx.doi.org/10.3389/fneng.2014.00025
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author Young, Brittany Mei
Nigogosyan, Zack
Remsik, Alexander
Walton, Léo M.
Song, Jie
Nair, Veena A.
Grogan, Scott W.
Tyler, Mitchell E.
Edwards, Dorothy Farrar
Caldera, Kristin
Sattin, Justin A.
Williams, Justin C.
Prabhakaran, Vivek
author_facet Young, Brittany Mei
Nigogosyan, Zack
Remsik, Alexander
Walton, Léo M.
Song, Jie
Nair, Veena A.
Grogan, Scott W.
Tyler, Mitchell E.
Edwards, Dorothy Farrar
Caldera, Kristin
Sattin, Justin A.
Williams, Justin C.
Prabhakaran, Vivek
author_sort Young, Brittany Mei
collection PubMed
description Brain-computer interface (BCI) technology is being incorporated into new stroke rehabilitation devices, but little is known about brain changes associated with its use. We collected anatomical and functional MRI of nine stroke patients with persistent upper extremity motor impairment before, during, and after therapy using a BCI system. Subjects were asked to perform finger tapping of the impaired hand during fMRI. Action Research Arm Test (ARAT), 9-Hole Peg Test (9-HPT), and Stroke Impact Scale (SIS) domains of Hand Function (HF) and Activities of Daily Living (ADL) were also assessed. Group-level analyses examined changes in whole-brain task-based functional connectivity (FC) to seed regions in the motor network observed during and after BCI therapy. Whole-brain FC analyses seeded in each thalamus showed FC increases from baseline at mid-therapy and post-therapy (p < 0.05). Changes in FC between seeds at both the network and the connection levels were examined for correlations with changes in behavioral measures. Average motor network FC was increased post-therapy, and changes in average network FC correlated (p < 0.05) with changes in performance on ARAT (R(2) = 0.21), 9-HPT (R(2) = 0.41), SIS HF (R(2) = 0.27), and SIS ADL (R(2) = 0.40). Multiple individual connections within the motor network were found to correlate in change from baseline with changes in behavioral measures. Many of these connections involved the thalamus, with change in each of four behavioral measures significantly correlating with change from baseline FC of at least one thalamic connection. These preliminary results show changes in FC that occur with the administration of rehabilitative therapy using a BCI system. The correlations noted between changes in FC measures and changes in behavioral outcomes indicate that both adaptive and maladaptive changes in FC may develop with this therapy and also suggest a brain-behavior relationship that may be stimulated by the neuromodulatory component of BCI therapy.
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spelling pubmed-40863212014-07-28 Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device Young, Brittany Mei Nigogosyan, Zack Remsik, Alexander Walton, Léo M. Song, Jie Nair, Veena A. Grogan, Scott W. Tyler, Mitchell E. Edwards, Dorothy Farrar Caldera, Kristin Sattin, Justin A. Williams, Justin C. Prabhakaran, Vivek Front Neuroeng Neuroscience Brain-computer interface (BCI) technology is being incorporated into new stroke rehabilitation devices, but little is known about brain changes associated with its use. We collected anatomical and functional MRI of nine stroke patients with persistent upper extremity motor impairment before, during, and after therapy using a BCI system. Subjects were asked to perform finger tapping of the impaired hand during fMRI. Action Research Arm Test (ARAT), 9-Hole Peg Test (9-HPT), and Stroke Impact Scale (SIS) domains of Hand Function (HF) and Activities of Daily Living (ADL) were also assessed. Group-level analyses examined changes in whole-brain task-based functional connectivity (FC) to seed regions in the motor network observed during and after BCI therapy. Whole-brain FC analyses seeded in each thalamus showed FC increases from baseline at mid-therapy and post-therapy (p < 0.05). Changes in FC between seeds at both the network and the connection levels were examined for correlations with changes in behavioral measures. Average motor network FC was increased post-therapy, and changes in average network FC correlated (p < 0.05) with changes in performance on ARAT (R(2) = 0.21), 9-HPT (R(2) = 0.41), SIS HF (R(2) = 0.27), and SIS ADL (R(2) = 0.40). Multiple individual connections within the motor network were found to correlate in change from baseline with changes in behavioral measures. Many of these connections involved the thalamus, with change in each of four behavioral measures significantly correlating with change from baseline FC of at least one thalamic connection. These preliminary results show changes in FC that occur with the administration of rehabilitative therapy using a BCI system. The correlations noted between changes in FC measures and changes in behavioral outcomes indicate that both adaptive and maladaptive changes in FC may develop with this therapy and also suggest a brain-behavior relationship that may be stimulated by the neuromodulatory component of BCI therapy. Frontiers Media S.A. 2014-07-08 /pmc/articles/PMC4086321/ /pubmed/25071547 http://dx.doi.org/10.3389/fneng.2014.00025 Text en Copyright © 2014 Young, Nigogosyan, Remsik, Walton, Song, Nair, Grogan, Tyler, Edwards, Caldera, Sattin, Williams and Prabhakaran. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Young, Brittany Mei
Nigogosyan, Zack
Remsik, Alexander
Walton, Léo M.
Song, Jie
Nair, Veena A.
Grogan, Scott W.
Tyler, Mitchell E.
Edwards, Dorothy Farrar
Caldera, Kristin
Sattin, Justin A.
Williams, Justin C.
Prabhakaran, Vivek
Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title_full Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title_fullStr Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title_full_unstemmed Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title_short Changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
title_sort changes in functional connectivity correlate with behavioral gains in stroke patients after therapy using a brain-computer interface device
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086321/
https://www.ncbi.nlm.nih.gov/pubmed/25071547
http://dx.doi.org/10.3389/fneng.2014.00025
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