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Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine

Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Ch...

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Autores principales: Hung, Tzu-Chieh, Lee, Wen-Yuan, Chen, Kuen-Bao, Chan, Yueh-Chiu, Chen, Calvin Yu-Chian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086518/
https://www.ncbi.nlm.nih.gov/pubmed/25045710
http://dx.doi.org/10.1155/2014/871576
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author Hung, Tzu-Chieh
Lee, Wen-Yuan
Chen, Kuen-Bao
Chan, Yueh-Chiu
Chen, Calvin Yu-Chian
author_facet Hung, Tzu-Chieh
Lee, Wen-Yuan
Chen, Kuen-Bao
Chan, Yueh-Chiu
Chen, Calvin Yu-Chian
author_sort Hung, Tzu-Chieh
collection PubMed
description Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM) database by simulating molecular docking and molecular dynamics could select candidate compounds, which may express MX2 against HIV. Saussureamine C, Crotalaburnine, and Precatorine are selected based on the highest docking score and other TCM compounds. The data from molecular dynamics are helpful in the analysis and detection of protein-ligand interactions. According to the docking poses, hydrophobic interactions, and hydrogen bond with structure variations, this research could assess the interaction between protein and ligand interaction. In addition to the detection of TCM compound efficacy, we suggest that Saussureamine C is better than the others in protein-ligand interaction and the structural variation to express MX2.
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spelling pubmed-40865182014-07-20 Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine Hung, Tzu-Chieh Lee, Wen-Yuan Chen, Kuen-Bao Chan, Yueh-Chiu Chen, Calvin Yu-Chian Biomed Res Int Research Article Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM) database by simulating molecular docking and molecular dynamics could select candidate compounds, which may express MX2 against HIV. Saussureamine C, Crotalaburnine, and Precatorine are selected based on the highest docking score and other TCM compounds. The data from molecular dynamics are helpful in the analysis and detection of protein-ligand interactions. According to the docking poses, hydrophobic interactions, and hydrogen bond with structure variations, this research could assess the interaction between protein and ligand interaction. In addition to the detection of TCM compound efficacy, we suggest that Saussureamine C is better than the others in protein-ligand interaction and the structural variation to express MX2. Hindawi Publishing Corporation 2014 2014-06-18 /pmc/articles/PMC4086518/ /pubmed/25045710 http://dx.doi.org/10.1155/2014/871576 Text en Copyright © 2014 Tzu-Chieh Hung et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hung, Tzu-Chieh
Lee, Wen-Yuan
Chen, Kuen-Bao
Chan, Yueh-Chiu
Chen, Calvin Yu-Chian
Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title_full Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title_fullStr Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title_full_unstemmed Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title_short Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine
title_sort insight into hiv of ifn-induced myxovirus resistance 2 (mx2) expressed by traditional chinese medicine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086518/
https://www.ncbi.nlm.nih.gov/pubmed/25045710
http://dx.doi.org/10.1155/2014/871576
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