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Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation
Adaptive introgression can provide novel genetic variation to fuel rapid evolutionary responses, though it may be counterbalanced by potential for detrimental disruption of the recipient genomic background. We examine the extent and impact of recent introgression of a strongly selected insecticide-r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086683/ https://www.ncbi.nlm.nih.gov/pubmed/24963649 http://dx.doi.org/10.1038/ncomms5248 |
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author | Clarkson, Chris S. Weetman, David Essandoh, John Yawson, Alexander E. Maslen, Gareth Manske, Magnus Field, Stuart G. Webster, Mark Antão, Tiago MacInnis, Bronwyn Kwiatkowski, Dominic Donnelly, Martin J. |
author_facet | Clarkson, Chris S. Weetman, David Essandoh, John Yawson, Alexander E. Maslen, Gareth Manske, Magnus Field, Stuart G. Webster, Mark Antão, Tiago MacInnis, Bronwyn Kwiatkowski, Dominic Donnelly, Martin J. |
author_sort | Clarkson, Chris S. |
collection | PubMed |
description | Adaptive introgression can provide novel genetic variation to fuel rapid evolutionary responses, though it may be counterbalanced by potential for detrimental disruption of the recipient genomic background. We examine the extent and impact of recent introgression of a strongly selected insecticide-resistance mutation (Vgsc-1014F) located within one of two exceptionally large genomic islands of divergence separating the Anopheles gambiae species pair. Here we show that transfer of the Vgsc mutation results in homogenization of the entire genomic island region (~1.5% of the genome) between species. Despite this massive disruption, introgression is clearly adaptive with a dramatic rise in frequency of Vgsc-1014F and no discernable impact on subsequent reproductive isolation between species. Our results show (1) how resilience of genomes to massive introgression can permit rapid adaptive response to anthropogenic selection and (2) that even extreme prominence of genomic islands of divergence can be an unreliable indicator of importance in speciation. |
format | Online Article Text |
id | pubmed-4086683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40866832014-07-09 Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation Clarkson, Chris S. Weetman, David Essandoh, John Yawson, Alexander E. Maslen, Gareth Manske, Magnus Field, Stuart G. Webster, Mark Antão, Tiago MacInnis, Bronwyn Kwiatkowski, Dominic Donnelly, Martin J. Nat Commun Article Adaptive introgression can provide novel genetic variation to fuel rapid evolutionary responses, though it may be counterbalanced by potential for detrimental disruption of the recipient genomic background. We examine the extent and impact of recent introgression of a strongly selected insecticide-resistance mutation (Vgsc-1014F) located within one of two exceptionally large genomic islands of divergence separating the Anopheles gambiae species pair. Here we show that transfer of the Vgsc mutation results in homogenization of the entire genomic island region (~1.5% of the genome) between species. Despite this massive disruption, introgression is clearly adaptive with a dramatic rise in frequency of Vgsc-1014F and no discernable impact on subsequent reproductive isolation between species. Our results show (1) how resilience of genomes to massive introgression can permit rapid adaptive response to anthropogenic selection and (2) that even extreme prominence of genomic islands of divergence can be an unreliable indicator of importance in speciation. Nature Pub. Group 2014-06-25 /pmc/articles/PMC4086683/ /pubmed/24963649 http://dx.doi.org/10.1038/ncomms5248 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Article Clarkson, Chris S. Weetman, David Essandoh, John Yawson, Alexander E. Maslen, Gareth Manske, Magnus Field, Stuart G. Webster, Mark Antão, Tiago MacInnis, Bronwyn Kwiatkowski, Dominic Donnelly, Martin J. Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation |
title | Adaptive introgression between Anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
title_full | Adaptive introgression between Anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
title_fullStr | Adaptive introgression between Anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
title_full_unstemmed | Adaptive introgression between Anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
title_short | Adaptive introgression between Anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
title_sort | adaptive introgression between anopheles sibling species eliminates a major genomic
island but not reproductive isolation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086683/ https://www.ncbi.nlm.nih.gov/pubmed/24963649 http://dx.doi.org/10.1038/ncomms5248 |
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