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Exploring the RING-Catalyzed Ubiquitin Transfer Mechanism by MD and QM/MM Calculations
Ubiquitylation is a universal mechanism for controlling cellular functions. A large family of ubiquitin E3 ligases (E3) mediates Ubiquitin (Ub) modification. To facilitate Ub transfer, RING E3 ligases bind both the substrate and ubiquitin E2 conjugating enzyme (E2) linked to Ub via a thioester bond...
Autores principales: | Zhen, Yunmei, Qin, Guangrong, Luo, Cheng, Jiang, Hualiang, Yu, Kunqian, Chen, Guanghui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086935/ https://www.ncbi.nlm.nih.gov/pubmed/25003393 http://dx.doi.org/10.1371/journal.pone.0101663 |
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