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Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We invest...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087012/ https://www.ncbi.nlm.nih.gov/pubmed/25003598 http://dx.doi.org/10.1371/journal.pone.0101852 |
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author | Kim, Hye Won Kim, Yang-Hyun Han, Kyungdo Nam, Ga Eun Kim, Gwang Seon Han, Byoung-Duck Lee, Anna Ahn, Ji Yong Ko, Byung Joon |
author_facet | Kim, Hye Won Kim, Yang-Hyun Han, Kyungdo Nam, Ga Eun Kim, Gwang Seon Han, Byoung-Duck Lee, Anna Ahn, Ji Yong Ko, Byung Joon |
author_sort | Kim, Hye Won |
collection | PubMed |
description | PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. SUBJECTS AND METHODS: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. RESULTS: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). CONCLUSIONS: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women. |
format | Online Article Text |
id | pubmed-4087012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40870122014-07-14 Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women Kim, Hye Won Kim, Yang-Hyun Han, Kyungdo Nam, Ga Eun Kim, Gwang Seon Han, Byoung-Duck Lee, Anna Ahn, Ji Yong Ko, Byung Joon PLoS One Research Article PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. SUBJECTS AND METHODS: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. RESULTS: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). CONCLUSIONS: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women. Public Library of Science 2014-07-08 /pmc/articles/PMC4087012/ /pubmed/25003598 http://dx.doi.org/10.1371/journal.pone.0101852 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kim, Hye Won Kim, Yang-Hyun Han, Kyungdo Nam, Ga Eun Kim, Gwang Seon Han, Byoung-Duck Lee, Anna Ahn, Ji Yong Ko, Byung Joon Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title | Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title_full | Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title_fullStr | Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title_full_unstemmed | Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title_short | Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women |
title_sort | atrophic gastritis: a related factor for osteoporosis in elderly women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087012/ https://www.ncbi.nlm.nih.gov/pubmed/25003598 http://dx.doi.org/10.1371/journal.pone.0101852 |
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