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Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women

PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We invest...

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Autores principales: Kim, Hye Won, Kim, Yang-Hyun, Han, Kyungdo, Nam, Ga Eun, Kim, Gwang Seon, Han, Byoung-Duck, Lee, Anna, Ahn, Ji Yong, Ko, Byung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087012/
https://www.ncbi.nlm.nih.gov/pubmed/25003598
http://dx.doi.org/10.1371/journal.pone.0101852
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author Kim, Hye Won
Kim, Yang-Hyun
Han, Kyungdo
Nam, Ga Eun
Kim, Gwang Seon
Han, Byoung-Duck
Lee, Anna
Ahn, Ji Yong
Ko, Byung Joon
author_facet Kim, Hye Won
Kim, Yang-Hyun
Han, Kyungdo
Nam, Ga Eun
Kim, Gwang Seon
Han, Byoung-Duck
Lee, Anna
Ahn, Ji Yong
Ko, Byung Joon
author_sort Kim, Hye Won
collection PubMed
description PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. SUBJECTS AND METHODS: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. RESULTS: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). CONCLUSIONS: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.
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spelling pubmed-40870122014-07-14 Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women Kim, Hye Won Kim, Yang-Hyun Han, Kyungdo Nam, Ga Eun Kim, Gwang Seon Han, Byoung-Duck Lee, Anna Ahn, Ji Yong Ko, Byung Joon PLoS One Research Article PURPOSE: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. SUBJECTS AND METHODS: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. RESULTS: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). CONCLUSIONS: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women. Public Library of Science 2014-07-08 /pmc/articles/PMC4087012/ /pubmed/25003598 http://dx.doi.org/10.1371/journal.pone.0101852 Text en © 2014 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kim, Hye Won
Kim, Yang-Hyun
Han, Kyungdo
Nam, Ga Eun
Kim, Gwang Seon
Han, Byoung-Duck
Lee, Anna
Ahn, Ji Yong
Ko, Byung Joon
Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title_full Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title_fullStr Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title_full_unstemmed Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title_short Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women
title_sort atrophic gastritis: a related factor for osteoporosis in elderly women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087012/
https://www.ncbi.nlm.nih.gov/pubmed/25003598
http://dx.doi.org/10.1371/journal.pone.0101852
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