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N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1

Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn(99), Asn(216), and Asn(350). In this report, we show the functional significance of N-glycosylation on HYAL1 functions. Using mass spectrometry, we demonstrated that...

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Detalles Bibliográficos
Autores principales:	Goto, Yuki, Niwa, Yuki, Suzuki, Takehiro, Uematsu, Shiho, Dohmae, Naoshi, Simizu, Siro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087149/ https://www.ncbi.nlm.nih.gov/pubmed/25009769 http://dx.doi.org/10.1016/j.fob.2014.06.001

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