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Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report
INTRODUCTION: The cardiovascular consequences related to amyotrophic lateral sclerosis are relatively underappreciated. The disease invokes a systematic degeneration of autonomic neurons leading to autonomic dysfunction. We therefore hypothesized that patients with amyotrophic lateral sclerosis may...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088295/ https://www.ncbi.nlm.nih.gov/pubmed/24961916 http://dx.doi.org/10.1186/1752-1947-8-224 |
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author | Shemisa, Kamal Kaelber, David Parikh, Sahil A Mackall, Judith A |
author_facet | Shemisa, Kamal Kaelber, David Parikh, Sahil A Mackall, Judith A |
author_sort | Shemisa, Kamal |
collection | PubMed |
description | INTRODUCTION: The cardiovascular consequences related to amyotrophic lateral sclerosis are relatively underappreciated. The disease invokes a systematic degeneration of autonomic neurons leading to autonomic dysfunction. We therefore hypothesized that patients with amyotrophic lateral sclerosis may have a predilection to the development of cardiac conduction disorders. CASE PRESENTATION: A 65-year-old Caucasian man with advanced amyotrophic lateral sclerosis presented with progressive dyspnea and palpitations. A previous evaluation attributed his dyspnea to neuromuscular weakness and he underwent a pulmonary evaluation. Pulmonary function tests did not indicate a worsening from baseline. An electrocardiogram was obtained which demonstrated new third degree atrioventricular block. A previously obtained electrocardiogram indicated normal sinus rhythm. On echocardiogram, a structurally normal heart was observed without significant valvular disease. He was offered a permanent dual chamber pacemaker for definitive treatment, however, he declined. CONCLUSIONS: We believe that his symptoms were probably attributable to atrioventricular block. Patients with advanced amyotrophic lateral sclerosis experience loss of heart rate variability and enhanced vasomotor responses. As patients progress later in the disease, sympathetic denervation and vagal predominance contribute to the development of atrioventricular block. We conducted a query using the Explorys database of patients with amyotrophic lateral sclerosis and heart block. The prevalence of heart block was estimated to be 25% higher in patients with the disease as compared to the general population. This is the first reported case that attempts to describe the relationship of atrioventricular block with amyotrophic lateral sclerosis. |
format | Online Article Text |
id | pubmed-4088295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40882952014-07-10 Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report Shemisa, Kamal Kaelber, David Parikh, Sahil A Mackall, Judith A J Med Case Rep Case Report INTRODUCTION: The cardiovascular consequences related to amyotrophic lateral sclerosis are relatively underappreciated. The disease invokes a systematic degeneration of autonomic neurons leading to autonomic dysfunction. We therefore hypothesized that patients with amyotrophic lateral sclerosis may have a predilection to the development of cardiac conduction disorders. CASE PRESENTATION: A 65-year-old Caucasian man with advanced amyotrophic lateral sclerosis presented with progressive dyspnea and palpitations. A previous evaluation attributed his dyspnea to neuromuscular weakness and he underwent a pulmonary evaluation. Pulmonary function tests did not indicate a worsening from baseline. An electrocardiogram was obtained which demonstrated new third degree atrioventricular block. A previously obtained electrocardiogram indicated normal sinus rhythm. On echocardiogram, a structurally normal heart was observed without significant valvular disease. He was offered a permanent dual chamber pacemaker for definitive treatment, however, he declined. CONCLUSIONS: We believe that his symptoms were probably attributable to atrioventricular block. Patients with advanced amyotrophic lateral sclerosis experience loss of heart rate variability and enhanced vasomotor responses. As patients progress later in the disease, sympathetic denervation and vagal predominance contribute to the development of atrioventricular block. We conducted a query using the Explorys database of patients with amyotrophic lateral sclerosis and heart block. The prevalence of heart block was estimated to be 25% higher in patients with the disease as compared to the general population. This is the first reported case that attempts to describe the relationship of atrioventricular block with amyotrophic lateral sclerosis. BioMed Central 2014-06-24 /pmc/articles/PMC4088295/ /pubmed/24961916 http://dx.doi.org/10.1186/1752-1947-8-224 Text en Copyright © 2014 Shemisa et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Shemisa, Kamal Kaelber, David Parikh, Sahil A Mackall, Judith A Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title | Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title_full | Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title_fullStr | Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title_full_unstemmed | Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title_short | Autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
title_sort | autonomic etiology of heart block in amyotrophic lateral sclerosis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088295/ https://www.ncbi.nlm.nih.gov/pubmed/24961916 http://dx.doi.org/10.1186/1752-1947-8-224 |
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