Cargando…
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice
BACKGROUND: Intraneuronal inclusions of TAR DNA-binding protein 43 (TDP-43) have been found in the majority of Amyotrophic Lateral Sclerosis (ALS) patients. Mutations in the gene encoding TDP-43 cause familial ALS. Transgenic mice expressing mutant TDP-43 with one such mutation (TDP-43 (A315T)) unde...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088917/ https://www.ncbi.nlm.nih.gov/pubmed/24938805 http://dx.doi.org/10.1186/1750-1326-9-24 |