Cargando…
Endoplasmic reticulum calcium stores in dendritic spines
Despite decades of research, the role of calcium stores in dendritic spines structure, function and plasticity is still debated. The reasons for this may have to do with the multitude of overlapping calcium handling machineries in the neuron, including stores, voltage and ligand gated channels, pump...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089118/ https://www.ncbi.nlm.nih.gov/pubmed/25071469 http://dx.doi.org/10.3389/fnana.2014.00064 |
_version_ | 1782325075075137536 |
---|---|
author | Segal, Menahem Korkotian, Eduard |
author_facet | Segal, Menahem Korkotian, Eduard |
author_sort | Segal, Menahem |
collection | PubMed |
description | Despite decades of research, the role of calcium stores in dendritic spines structure, function and plasticity is still debated. The reasons for this may have to do with the multitude of overlapping calcium handling machineries in the neuron, including stores, voltage and ligand gated channels, pumps and transporters. Also, different cells in the brain are endowed with calcium stores that are activated by different receptor types, and their differential compartmentalization in dendrites, spines and presynaptic terminals complicates their analysis. In the present review we address several key issues, including the role of calcium stores in synaptic plasticity, their role during development, in stress and in neurodegenerative diseases. Apparently, there is increasing evidence for a crucial role of calcium stores, especially of the ryanodine species, in synaptic plasticity and neuronal survival. |
format | Online Article Text |
id | pubmed-4089118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40891182014-07-28 Endoplasmic reticulum calcium stores in dendritic spines Segal, Menahem Korkotian, Eduard Front Neuroanat Neuroscience Despite decades of research, the role of calcium stores in dendritic spines structure, function and plasticity is still debated. The reasons for this may have to do with the multitude of overlapping calcium handling machineries in the neuron, including stores, voltage and ligand gated channels, pumps and transporters. Also, different cells in the brain are endowed with calcium stores that are activated by different receptor types, and their differential compartmentalization in dendrites, spines and presynaptic terminals complicates their analysis. In the present review we address several key issues, including the role of calcium stores in synaptic plasticity, their role during development, in stress and in neurodegenerative diseases. Apparently, there is increasing evidence for a crucial role of calcium stores, especially of the ryanodine species, in synaptic plasticity and neuronal survival. Frontiers Media S.A. 2014-07-09 /pmc/articles/PMC4089118/ /pubmed/25071469 http://dx.doi.org/10.3389/fnana.2014.00064 Text en Copyright © 2014 Segal and Korkotian. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Segal, Menahem Korkotian, Eduard Endoplasmic reticulum calcium stores in dendritic spines |
title | Endoplasmic reticulum calcium stores in dendritic spines |
title_full | Endoplasmic reticulum calcium stores in dendritic spines |
title_fullStr | Endoplasmic reticulum calcium stores in dendritic spines |
title_full_unstemmed | Endoplasmic reticulum calcium stores in dendritic spines |
title_short | Endoplasmic reticulum calcium stores in dendritic spines |
title_sort | endoplasmic reticulum calcium stores in dendritic spines |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089118/ https://www.ncbi.nlm.nih.gov/pubmed/25071469 http://dx.doi.org/10.3389/fnana.2014.00064 |
work_keys_str_mv | AT segalmenahem endoplasmicreticulumcalciumstoresindendriticspines AT korkotianeduard endoplasmicreticulumcalciumstoresindendriticspines |