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Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer

Background. ABO blood group and risk of squamous cell carcinoma of esophagus have been reported by many studies, but there is no discipline that had provided association with the genotype and gene frequency by population statics. Methods. We conducted a case-control study on 480 patients with squamo...

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Autores principales: Kumar, Narender, Kapoor, Akhil, Kalwar, Ashok, Narayan, Satya, Singhal, Mukesh Kumar, Kumar, Akhender, Mewara, Abhishek, Bardia, Megh Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089147/
https://www.ncbi.nlm.nih.gov/pubmed/25054136
http://dx.doi.org/10.1155/2014/286810
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author Kumar, Narender
Kapoor, Akhil
Kalwar, Ashok
Narayan, Satya
Singhal, Mukesh Kumar
Kumar, Akhender
Mewara, Abhishek
Bardia, Megh Raj
author_facet Kumar, Narender
Kapoor, Akhil
Kalwar, Ashok
Narayan, Satya
Singhal, Mukesh Kumar
Kumar, Akhender
Mewara, Abhishek
Bardia, Megh Raj
author_sort Kumar, Narender
collection PubMed
description Background. ABO blood group and risk of squamous cell carcinoma of esophagus have been reported by many studies, but there is no discipline that had provided association with the genotype and gene frequency by population statics. Methods. We conducted a case-control study on 480 patients with squamous cell carcinoma of the esophagus and 480 noncancer patients. ABO blood group was determined by presence of antigen with the help of monoclonal antibody. Chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were calculated by statistical methods, and gene frequencies were calculated by Hardy-Weinberg model. Results. We observed significant associations between ABO genotype and squamous cell carcinoma of esophagus. OR (95% CIs) was 1.69 (1.31–2.19) for presence of B antigen allele relative to its absence (P < 0.0001); in female subgroup OR (95% CIs) observed at 1.84 (1.27–2.65) was statistically significant (P = 0.001). SCC of esophagus shows significant difference in comparison to general population; blood group B is found to be higher in incidence (P = 0.0001). Increased risk of cancer was observed with absence of Rh antigen (P = 0.0001). Relatively increased gene frequency of q[B] allele is observed more significantly in female cancer patients (P = 0.003). Conclusion. Statistically significant association between squamous cell carcinoma of the esophagus and ABO and Rh genotype is identified by this study. Sex and anatomical site of cancer also present with statistically significant relative association. However, larger randomised trials are required to establish the hypothesis.
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spelling pubmed-40891472014-07-22 Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer Kumar, Narender Kapoor, Akhil Kalwar, Ashok Narayan, Satya Singhal, Mukesh Kumar Kumar, Akhender Mewara, Abhishek Bardia, Megh Raj Biomed Res Int Research Article Background. ABO blood group and risk of squamous cell carcinoma of esophagus have been reported by many studies, but there is no discipline that had provided association with the genotype and gene frequency by population statics. Methods. We conducted a case-control study on 480 patients with squamous cell carcinoma of the esophagus and 480 noncancer patients. ABO blood group was determined by presence of antigen with the help of monoclonal antibody. Chi-square test and odds ratio (OR) with 95% confidence intervals (CIs) were calculated by statistical methods, and gene frequencies were calculated by Hardy-Weinberg model. Results. We observed significant associations between ABO genotype and squamous cell carcinoma of esophagus. OR (95% CIs) was 1.69 (1.31–2.19) for presence of B antigen allele relative to its absence (P < 0.0001); in female subgroup OR (95% CIs) observed at 1.84 (1.27–2.65) was statistically significant (P = 0.001). SCC of esophagus shows significant difference in comparison to general population; blood group B is found to be higher in incidence (P = 0.0001). Increased risk of cancer was observed with absence of Rh antigen (P = 0.0001). Relatively increased gene frequency of q[B] allele is observed more significantly in female cancer patients (P = 0.003). Conclusion. Statistically significant association between squamous cell carcinoma of the esophagus and ABO and Rh genotype is identified by this study. Sex and anatomical site of cancer also present with statistically significant relative association. However, larger randomised trials are required to establish the hypothesis. Hindawi Publishing Corporation 2014 2014-06-19 /pmc/articles/PMC4089147/ /pubmed/25054136 http://dx.doi.org/10.1155/2014/286810 Text en Copyright © 2014 Narender Kumar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kumar, Narender
Kapoor, Akhil
Kalwar, Ashok
Narayan, Satya
Singhal, Mukesh Kumar
Kumar, Akhender
Mewara, Abhishek
Bardia, Megh Raj
Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title_full Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title_fullStr Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title_full_unstemmed Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title_short Allele Frequency of ABO Blood Group Antigen and the Risk of Esophageal Cancer
title_sort allele frequency of abo blood group antigen and the risk of esophageal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089147/
https://www.ncbi.nlm.nih.gov/pubmed/25054136
http://dx.doi.org/10.1155/2014/286810
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