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Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications
Background: Wound healing disorders are probably the most common post-transplantation surgical complications. It is thought that wound healing disturbance occurs due to antiproliferative effects of immunosuppressive drugs. On the other hand, success of transplantation is dependent on immunosuppressi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Avicenna Organ Transplantation Institute
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089281/ https://www.ncbi.nlm.nih.gov/pubmed/25013627 |
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author | Pourmand, G. R. Dehghani, S. Saraji, A. Khaki, S. Mortazavi, S. H. Mehrsai, A. Sajadi, H. |
author_facet | Pourmand, G. R. Dehghani, S. Saraji, A. Khaki, S. Mortazavi, S. H. Mehrsai, A. Sajadi, H. |
author_sort | Pourmand, G. R. |
collection | PubMed |
description | Background: Wound healing disorders are probably the most common post-transplantation surgical complications. It is thought that wound healing disturbance occurs due to antiproliferative effects of immunosuppressive drugs. On the other hand, success of transplantation is dependent on immunosuppressive therapies. Antihuman thymocyte globulin (ATG) has been widely used as induction therapy but the impact of this treatment on wound healing is not fully understood. Objective: To investigate wound healing complications after ATG therapy in renal transplant recipients. Methods: The medical records of 333 kidney transplant recipients were assessed for wound healing disorders. Among these patients, 92 received ATG and 5 doses of 1.5 mg/kg ATG along with the standard protocol of drugs. Results: The mean age of patients was 38.9 years. Of 333 recipients, 92 (23.7%) received ATG; 21 (6.3%) developed wound healing complications. There was a significant relationship between ATG therapy and wound complications (p=0.034). Also, women were more likely to develop wound healing disorders than men (p=0.002). No statistical difference was observed between age and wound healing complication (p=0.28). There was no significant difference between the mean duration of hospitalization between ATG and Non-ATG group (p=0.9). Conclusion: ATG increases the risk of overall wound complications. It is needed to pay more attention to the patients treated with this immunosuppressant to avoid the risk of re-interventions, lessen the duration of hospitalization and decrease the impairment of graft function. |
format | Online Article Text |
id | pubmed-4089281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Avicenna Organ Transplantation Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-40892812014-07-10 Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications Pourmand, G. R. Dehghani, S. Saraji, A. Khaki, S. Mortazavi, S. H. Mehrsai, A. Sajadi, H. Int J Organ Transplant Med Original Article Background: Wound healing disorders are probably the most common post-transplantation surgical complications. It is thought that wound healing disturbance occurs due to antiproliferative effects of immunosuppressive drugs. On the other hand, success of transplantation is dependent on immunosuppressive therapies. Antihuman thymocyte globulin (ATG) has been widely used as induction therapy but the impact of this treatment on wound healing is not fully understood. Objective: To investigate wound healing complications after ATG therapy in renal transplant recipients. Methods: The medical records of 333 kidney transplant recipients were assessed for wound healing disorders. Among these patients, 92 received ATG and 5 doses of 1.5 mg/kg ATG along with the standard protocol of drugs. Results: The mean age of patients was 38.9 years. Of 333 recipients, 92 (23.7%) received ATG; 21 (6.3%) developed wound healing complications. There was a significant relationship between ATG therapy and wound complications (p=0.034). Also, women were more likely to develop wound healing disorders than men (p=0.002). No statistical difference was observed between age and wound healing complication (p=0.28). There was no significant difference between the mean duration of hospitalization between ATG and Non-ATG group (p=0.9). Conclusion: ATG increases the risk of overall wound complications. It is needed to pay more attention to the patients treated with this immunosuppressant to avoid the risk of re-interventions, lessen the duration of hospitalization and decrease the impairment of graft function. Avicenna Organ Transplantation Institute 2012 2012-05-01 /pmc/articles/PMC4089281/ /pubmed/25013627 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Pourmand, G. R. Dehghani, S. Saraji, A. Khaki, S. Mortazavi, S. H. Mehrsai, A. Sajadi, H. Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title | Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title_full | Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title_fullStr | Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title_full_unstemmed | Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title_short | Relationship between Post-kidney Transplantation Antithymocyte Globulin Therapy and Wound Healing Complications |
title_sort | relationship between post-kidney transplantation antithymocyte globulin therapy and wound healing complications |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089281/ https://www.ncbi.nlm.nih.gov/pubmed/25013627 |
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