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Mechanisms of arterial calcifications and consequences for cardiovascular function

Cardiovascular complications are the leading cause of mortality in chronic (CKD) and end-stage renal disease (ESRD). The risk of developing cardiovascular complications is associated with changes in the structure and function of the arterial system, which are in many aspects similar to those occurri...

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Autor principal: London, Gérard M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089689/
https://www.ncbi.nlm.nih.gov/pubmed/25019027
http://dx.doi.org/10.1038/kisup.2013.92
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author London, Gérard M
author_facet London, Gérard M
author_sort London, Gérard M
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description Cardiovascular complications are the leading cause of mortality in chronic (CKD) and end-stage renal disease (ESRD). The risk of developing cardiovascular complications is associated with changes in the structure and function of the arterial system, which are in many aspects similar to those occurring with aging. The presence of traditional risk factors does not fully explain the extension and severity of arterial disease. Therefore, other factors associated with CKD and ESRD must also be involved. Arterial calcification (AC) is a common complication of CKD and ESRD, and the extent of AC in general population as well as in patients with CKD is predictive of subsequent cardiovascular mortality beyond established conventional risk factors. AC is an active process similar to bone formation that implicates a variety of proteins involved in bone and mineral metabolism and is considered part of a systemic dysfunction defined as CKD-associated mineral and bone disorder (CKD-MBD).
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spelling pubmed-40896892014-07-11 Mechanisms of arterial calcifications and consequences for cardiovascular function London, Gérard M Kidney Int Suppl (2011) Review Cardiovascular complications are the leading cause of mortality in chronic (CKD) and end-stage renal disease (ESRD). The risk of developing cardiovascular complications is associated with changes in the structure and function of the arterial system, which are in many aspects similar to those occurring with aging. The presence of traditional risk factors does not fully explain the extension and severity of arterial disease. Therefore, other factors associated with CKD and ESRD must also be involved. Arterial calcification (AC) is a common complication of CKD and ESRD, and the extent of AC in general population as well as in patients with CKD is predictive of subsequent cardiovascular mortality beyond established conventional risk factors. AC is an active process similar to bone formation that implicates a variety of proteins involved in bone and mineral metabolism and is considered part of a systemic dysfunction defined as CKD-associated mineral and bone disorder (CKD-MBD). Nature Publishing Group 2013-12 2013-11-27 /pmc/articles/PMC4089689/ /pubmed/25019027 http://dx.doi.org/10.1038/kisup.2013.92 Text en Copyright © 2013 International Society of Nephrology
spellingShingle Review
London, Gérard M
Mechanisms of arterial calcifications and consequences for cardiovascular function
title Mechanisms of arterial calcifications and consequences for cardiovascular function
title_full Mechanisms of arterial calcifications and consequences for cardiovascular function
title_fullStr Mechanisms of arterial calcifications and consequences for cardiovascular function
title_full_unstemmed Mechanisms of arterial calcifications and consequences for cardiovascular function
title_short Mechanisms of arterial calcifications and consequences for cardiovascular function
title_sort mechanisms of arterial calcifications and consequences for cardiovascular function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089689/
https://www.ncbi.nlm.nih.gov/pubmed/25019027
http://dx.doi.org/10.1038/kisup.2013.92
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