Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Melanocortin 4 receptors (Mc4rs) are expressed by extra-hypothalamic neurons including cholinergic autonomic pre-ganglionic neurons. However, whether Mc4rs in these neurons are required to control energy and glucose homeostasis is unclear. Here we report that Mc4rs in sympathetic, but not parasympat...

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Autores principales: Berglund, Eric D., Liu, Tiemin, Kong, Xingxing, Sohn, Jong-Woo, Vong, Linh, Deng, Zhuo, Lee, Charlotte E., Lee, Syann, Williams, Kevin W., Olson, David P., Scherer, Philipp E., Lowell, Bradford B., Elmquist, Joel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090093/
https://www.ncbi.nlm.nih.gov/pubmed/24908101
http://dx.doi.org/10.1038/nn.3737
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author Berglund, Eric D.
Liu, Tiemin
Kong, Xingxing
Sohn, Jong-Woo
Vong, Linh
Deng, Zhuo
Lee, Charlotte E.
Lee, Syann
Williams, Kevin W.
Olson, David P.
Scherer, Philipp E.
Lowell, Bradford B.
Elmquist, Joel K.
author_facet Berglund, Eric D.
Liu, Tiemin
Kong, Xingxing
Sohn, Jong-Woo
Vong, Linh
Deng, Zhuo
Lee, Charlotte E.
Lee, Syann
Williams, Kevin W.
Olson, David P.
Scherer, Philipp E.
Lowell, Bradford B.
Elmquist, Joel K.
author_sort Berglund, Eric D.
collection PubMed
description Melanocortin 4 receptors (Mc4rs) are expressed by extra-hypothalamic neurons including cholinergic autonomic pre-ganglionic neurons. However, whether Mc4rs in these neurons are required to control energy and glucose homeostasis is unclear. Here we report that Mc4rs in sympathetic, but not parasympathetic, pre-ganglionic neurons are required to regulate energy expenditure and body weight including brown and white adipose tissue thermogenic responses to diet and cold exposure. In addition, deletion of Mc4rs in both sympathetic and parasympathetic cholinergic neurons impairs glucose homeostasis.
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spelling pubmed-40900932015-01-01 Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia Berglund, Eric D. Liu, Tiemin Kong, Xingxing Sohn, Jong-Woo Vong, Linh Deng, Zhuo Lee, Charlotte E. Lee, Syann Williams, Kevin W. Olson, David P. Scherer, Philipp E. Lowell, Bradford B. Elmquist, Joel K. Nat Neurosci Article Melanocortin 4 receptors (Mc4rs) are expressed by extra-hypothalamic neurons including cholinergic autonomic pre-ganglionic neurons. However, whether Mc4rs in these neurons are required to control energy and glucose homeostasis is unclear. Here we report that Mc4rs in sympathetic, but not parasympathetic, pre-ganglionic neurons are required to regulate energy expenditure and body weight including brown and white adipose tissue thermogenic responses to diet and cold exposure. In addition, deletion of Mc4rs in both sympathetic and parasympathetic cholinergic neurons impairs glucose homeostasis. 2014-06-08 2014-07 /pmc/articles/PMC4090093/ /pubmed/24908101 http://dx.doi.org/10.1038/nn.3737 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Berglund, Eric D.
Liu, Tiemin
Kong, Xingxing
Sohn, Jong-Woo
Vong, Linh
Deng, Zhuo
Lee, Charlotte E.
Lee, Syann
Williams, Kevin W.
Olson, David P.
Scherer, Philipp E.
Lowell, Bradford B.
Elmquist, Joel K.
Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title_full Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title_fullStr Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title_full_unstemmed Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title_short Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
title_sort melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090093/
https://www.ncbi.nlm.nih.gov/pubmed/24908101
http://dx.doi.org/10.1038/nn.3737
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