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A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging
Morphological imaging precedes lesion-specific visualization in magnetic resonance imaging (MRI) because of the superior ability of this technique to depict tissue morphology with excellent spatial and temporal resolutions. To achieve lesion-specific visualization of tumors by MRI, we investigated t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090184/ https://www.ncbi.nlm.nih.gov/pubmed/25007334 http://dx.doi.org/10.1371/journal.pone.0102132 |
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author | Suzuki, Yoshikazu Iida, Mitsuru Miura, Iwao Inubushi, Toshiro Morikawa, Shigehiro |
author_facet | Suzuki, Yoshikazu Iida, Mitsuru Miura, Iwao Inubushi, Toshiro Morikawa, Shigehiro |
author_sort | Suzuki, Yoshikazu |
collection | PubMed |
description | Morphological imaging precedes lesion-specific visualization in magnetic resonance imaging (MRI) because of the superior ability of this technique to depict tissue morphology with excellent spatial and temporal resolutions. To achieve lesion-specific visualization of tumors by MRI, we investigated the availability of a novel polymer-based tracer. Although the (13)C nucleus is a candidate for a detection nucleus because of its low background signal in the body, the low magnetic resonance sensitivity of the nucleus needs to be resolved before developing a (13)C-based tracer. In order to overcome this problem, we enriched polyethylene glycol (PEG), a biocompatible polymer, with (13)C atoms. (13)C-PEG40,000 ((13)C-PEG with an average molecular weight of 40 kDa) emitted a single (13)C signal with a high signal-to-noise ratio due to its ability to maintain signal sharpness, as was confirmed by in vivo investigation, and displayed a chemical shift sufficiently distinct from that of endogenous fat. (13)C-PEG40,000 intravenously injected into mice showed long retention in circulation, leading to its effective accumulation in tumors reflecting the well-known phenomenon that macromolecules accumulate in tumors because of leaky tumor capillaries. These properties of (13)C-PEG40,000 allowed visualization of tumors in mice by (13)C spectroscopic imaging. These findings suggest that a technique based on (13)C-PEG is a promising strategy for tumor detection. |
format | Online Article Text |
id | pubmed-4090184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40901842014-07-14 A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging Suzuki, Yoshikazu Iida, Mitsuru Miura, Iwao Inubushi, Toshiro Morikawa, Shigehiro PLoS One Research Article Morphological imaging precedes lesion-specific visualization in magnetic resonance imaging (MRI) because of the superior ability of this technique to depict tissue morphology with excellent spatial and temporal resolutions. To achieve lesion-specific visualization of tumors by MRI, we investigated the availability of a novel polymer-based tracer. Although the (13)C nucleus is a candidate for a detection nucleus because of its low background signal in the body, the low magnetic resonance sensitivity of the nucleus needs to be resolved before developing a (13)C-based tracer. In order to overcome this problem, we enriched polyethylene glycol (PEG), a biocompatible polymer, with (13)C atoms. (13)C-PEG40,000 ((13)C-PEG with an average molecular weight of 40 kDa) emitted a single (13)C signal with a high signal-to-noise ratio due to its ability to maintain signal sharpness, as was confirmed by in vivo investigation, and displayed a chemical shift sufficiently distinct from that of endogenous fat. (13)C-PEG40,000 intravenously injected into mice showed long retention in circulation, leading to its effective accumulation in tumors reflecting the well-known phenomenon that macromolecules accumulate in tumors because of leaky tumor capillaries. These properties of (13)C-PEG40,000 allowed visualization of tumors in mice by (13)C spectroscopic imaging. These findings suggest that a technique based on (13)C-PEG is a promising strategy for tumor detection. Public Library of Science 2014-07-09 /pmc/articles/PMC4090184/ /pubmed/25007334 http://dx.doi.org/10.1371/journal.pone.0102132 Text en © 2014 Suzuki et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Suzuki, Yoshikazu Iida, Mitsuru Miura, Iwao Inubushi, Toshiro Morikawa, Shigehiro A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title | A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title_full | A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title_fullStr | A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title_full_unstemmed | A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title_short | A Polymer-Based Magnetic Resonance Tracer for Visualization of Solid Tumors by (13)C Spectroscopic Imaging |
title_sort | polymer-based magnetic resonance tracer for visualization of solid tumors by (13)c spectroscopic imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090184/ https://www.ncbi.nlm.nih.gov/pubmed/25007334 http://dx.doi.org/10.1371/journal.pone.0102132 |
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