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Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

BACKGROUND: Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated...

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Autores principales: Dai, Dongjun, Chen, Yong, Ru, Ping, Zhou, Xingyu, Tao, Jianmin, Ye, Huadan, Hong, Qingxiao, Tang, Linlin, Pan, Guanghui, Lin, Danfeng, Gong, Qiongyao, Lv, Yuelong, Xu, Leiting, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090395/
https://www.ncbi.nlm.nih.gov/pubmed/24972609
http://dx.doi.org/10.1186/1746-1596-9-129
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author Dai, Dongjun
Chen, Yong
Ru, Ping
Zhou, Xingyu
Tao, Jianmin
Ye, Huadan
Hong, Qingxiao
Tang, Linlin
Pan, Guanghui
Lin, Danfeng
Gong, Qiongyao
Lv, Yuelong
Xu, Leiting
Duan, Shiwei
author_facet Dai, Dongjun
Chen, Yong
Ru, Ping
Zhou, Xingyu
Tao, Jianmin
Ye, Huadan
Hong, Qingxiao
Tang, Linlin
Pan, Guanghui
Lin, Danfeng
Gong, Qiongyao
Lv, Yuelong
Xu, Leiting
Duan, Shiwei
author_sort Dai, Dongjun
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA. METHODS: Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls. RESULTS: Meta-analyses showed that TAP2-379Ile allele was significantly associated with an increased risk of RA (p = 0.0002, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.18-1.74). This association was further shown only in the dominant model (p = 0.006, OR = 1.59, 95% CI = 1.14-2.22). Subgroup analyses by ethnicity revealed that the association of TAP2-379Ile was significant in Asians (p = 0.03, OR = 1.38, 95% CI = 1.04-1.83). In addition, another significant association of TAP2-565Thr allele with RA was observed in Europeans (p = 0.002, OR = 1.62, 95% CI = 1.20-2.20). CONCLUSIONS: Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk in the dominant effect model. Subgroup analyses by ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and TAP2-565Thr increased the risk of RA by 38% in Europeans. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700
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spelling pubmed-40903952014-07-11 Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis Dai, Dongjun Chen, Yong Ru, Ping Zhou, Xingyu Tao, Jianmin Ye, Huadan Hong, Qingxiao Tang, Linlin Pan, Guanghui Lin, Danfeng Gong, Qiongyao Lv, Yuelong Xu, Leiting Duan, Shiwei Diagn Pathol Research BACKGROUND: Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA. METHODS: Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls. RESULTS: Meta-analyses showed that TAP2-379Ile allele was significantly associated with an increased risk of RA (p = 0.0002, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.18-1.74). This association was further shown only in the dominant model (p = 0.006, OR = 1.59, 95% CI = 1.14-2.22). Subgroup analyses by ethnicity revealed that the association of TAP2-379Ile was significant in Asians (p = 0.03, OR = 1.38, 95% CI = 1.04-1.83). In addition, another significant association of TAP2-565Thr allele with RA was observed in Europeans (p = 0.002, OR = 1.62, 95% CI = 1.20-2.20). CONCLUSIONS: Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk in the dominant effect model. Subgroup analyses by ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and TAP2-565Thr increased the risk of RA by 38% in Europeans. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700 BioMed Central 2014-06-27 /pmc/articles/PMC4090395/ /pubmed/24972609 http://dx.doi.org/10.1186/1746-1596-9-129 Text en Copyright © 2014 Dai et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Dai, Dongjun
Chen, Yong
Ru, Ping
Zhou, Xingyu
Tao, Jianmin
Ye, Huadan
Hong, Qingxiao
Tang, Linlin
Pan, Guanghui
Lin, Danfeng
Gong, Qiongyao
Lv, Yuelong
Xu, Leiting
Duan, Shiwei
Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title_full Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title_fullStr Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title_full_unstemmed Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title_short Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis
title_sort significant association between tap2 polymorphisms and rheumatoid arthritis: a meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090395/
https://www.ncbi.nlm.nih.gov/pubmed/24972609
http://dx.doi.org/10.1186/1746-1596-9-129
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