Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

Detalles Bibliográficos
Autores principales: Brunet, Aurélie, Aslam, Tashfeen, Bradley, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090417/
https://www.ncbi.nlm.nih.gov/pubmed/24856065
http://dx.doi.org/10.1016/j.bmcl.2014.04.090
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author Brunet, Aurélie
Aslam, Tashfeen
Bradley, Mark
author_facet Brunet, Aurélie
Aslam, Tashfeen
Bradley, Mark
author_sort Brunet, Aurélie
collection PubMed
description Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.
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spelling pubmed-40904172014-07-15 Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B Brunet, Aurélie Aslam, Tashfeen Bradley, Mark Bioorg Med Chem Lett Article Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated. Elsevier Science Ltd 2014-07-15 /pmc/articles/PMC4090417/ /pubmed/24856065 http://dx.doi.org/10.1016/j.bmcl.2014.04.090 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Brunet, Aurélie
Aslam, Tashfeen
Bradley, Mark
Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title_full Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title_fullStr Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title_full_unstemmed Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title_short Separating the isomers—Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B
title_sort separating the isomers—efficient synthesis of the n-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine b
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090417/
https://www.ncbi.nlm.nih.gov/pubmed/24856065
http://dx.doi.org/10.1016/j.bmcl.2014.04.090
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