The Regulatory Role of Activating Transcription Factor 2 in Inflammation

Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c-Jun and c-Fos, ATF2 responds to stress-related stimuli and may thereby influence cell proliferation, in...

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Detalles Bibliográficos
Autores principales: Yu, Tao, Li, Yong Jun, Bian, Ai Hong, Zuo, Hui Bin, Zhu, Ti Wen, Ji, Sheng Xiang, Kong, Fanming, Yin, De Qing, Wang, Chuan Bao, Wang, Zi Fu, Wang, Hong Qun, Yang, Yanyan, Yoo, Byong Chul, Cho, Jae Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090481/
https://www.ncbi.nlm.nih.gov/pubmed/25049453
http://dx.doi.org/10.1155/2014/950472
Descripción
Sumario:Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c-Jun and c-Fos, ATF2 responds to stress-related stimuli and may thereby influence cell proliferation, inflammation, apoptosis, oncogenesis, neurological development and function, and skeletal remodeling. Recent studies clarify the regulatory role of ATF2 in inflammation and describe potential inhibitors of this protein. In this paper, we summarize the properties and functions of ATF2 and explore potential applications of ATF2 inhibitors as tools for research and for the development of immunosuppressive and anti-inflammatory drugs.

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