We Are Ageing

Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have be...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolovou, Genovefa D., Kolovou, Vana, Mavrogeni, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090574/
https://www.ncbi.nlm.nih.gov/pubmed/25045704
http://dx.doi.org/10.1155/2014/808307
_version_ 1782480664599199744
author Kolovou, Genovefa D.
Kolovou, Vana
Mavrogeni, Sophie
author_facet Kolovou, Genovefa D.
Kolovou, Vana
Mavrogeni, Sophie
author_sort Kolovou, Genovefa D.
collection PubMed
description Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
format Online
Article
Text
id pubmed-4090574
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40905742014-07-20 We Are Ageing Kolovou, Genovefa D. Kolovou, Vana Mavrogeni, Sophie Biomed Res Int Review Article Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity. Hindawi Publishing Corporation 2014 2014-06-22 /pmc/articles/PMC4090574/ /pubmed/25045704 http://dx.doi.org/10.1155/2014/808307 Text en Copyright © 2014 Genovefa D. Kolovou et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kolovou, Genovefa D.
Kolovou, Vana
Mavrogeni, Sophie
We Are Ageing
title We Are Ageing
title_full We Are Ageing
title_fullStr We Are Ageing
title_full_unstemmed We Are Ageing
title_short We Are Ageing
title_sort we are ageing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090574/
https://www.ncbi.nlm.nih.gov/pubmed/25045704
http://dx.doi.org/10.1155/2014/808307
work_keys_str_mv AT kolovougenovefad weareageing
AT kolovouvana weareageing
AT mavrogenisophie weareageing

Ejemplares similares