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Handling tRNA introns, archaeal way and eukaryotic way
Introns are found in various tRNA genes in all the three kingdoms of life. Especially, archaeal and eukaryotic genomes are good sources of tRNA introns that are removed by proteinaceous splicing machinery. Most intron-containing tRNA genes both in archaea and eukaryotes possess an intron at a so-cal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090602/ https://www.ncbi.nlm.nih.gov/pubmed/25071838 http://dx.doi.org/10.3389/fgene.2014.00213 |
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author | Yoshihisa, Tohru |
author_facet | Yoshihisa, Tohru |
author_sort | Yoshihisa, Tohru |
collection | PubMed |
description | Introns are found in various tRNA genes in all the three kingdoms of life. Especially, archaeal and eukaryotic genomes are good sources of tRNA introns that are removed by proteinaceous splicing machinery. Most intron-containing tRNA genes both in archaea and eukaryotes possess an intron at a so-called canonical position, one nucleotide 3′ to their anticodon, while recent bioinformatics have revealed unusual types of tRNA introns and their derivatives especially in archaeal genomes. Gain and loss of tRNA introns during various stages of evolution are obvious both in archaea and eukaryotes from analyses of comparative genomics. The splicing of tRNA molecules has been studied extensively from biochemical and cell biological points of view, and such analyses of eukaryotic systems provided interesting findings in the past years. Here, I summarize recent progresses in the analyses of tRNA introns and the splicing process, and try to clarify new and old questions to be solved in the next stages. |
format | Online Article Text |
id | pubmed-4090602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40906022014-07-28 Handling tRNA introns, archaeal way and eukaryotic way Yoshihisa, Tohru Front Genet Genetics Introns are found in various tRNA genes in all the three kingdoms of life. Especially, archaeal and eukaryotic genomes are good sources of tRNA introns that are removed by proteinaceous splicing machinery. Most intron-containing tRNA genes both in archaea and eukaryotes possess an intron at a so-called canonical position, one nucleotide 3′ to their anticodon, while recent bioinformatics have revealed unusual types of tRNA introns and their derivatives especially in archaeal genomes. Gain and loss of tRNA introns during various stages of evolution are obvious both in archaea and eukaryotes from analyses of comparative genomics. The splicing of tRNA molecules has been studied extensively from biochemical and cell biological points of view, and such analyses of eukaryotic systems provided interesting findings in the past years. Here, I summarize recent progresses in the analyses of tRNA introns and the splicing process, and try to clarify new and old questions to be solved in the next stages. Frontiers Media S.A. 2014-07-10 /pmc/articles/PMC4090602/ /pubmed/25071838 http://dx.doi.org/10.3389/fgene.2014.00213 Text en Copyright © 2014 Yoshihisa. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Yoshihisa, Tohru Handling tRNA introns, archaeal way and eukaryotic way |
title | Handling tRNA introns, archaeal way and eukaryotic way |
title_full | Handling tRNA introns, archaeal way and eukaryotic way |
title_fullStr | Handling tRNA introns, archaeal way and eukaryotic way |
title_full_unstemmed | Handling tRNA introns, archaeal way and eukaryotic way |
title_short | Handling tRNA introns, archaeal way and eukaryotic way |
title_sort | handling trna introns, archaeal way and eukaryotic way |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090602/ https://www.ncbi.nlm.nih.gov/pubmed/25071838 http://dx.doi.org/10.3389/fgene.2014.00213 |
work_keys_str_mv | AT yoshihisatohru handlingtrnaintronsarchaealwayandeukaryoticway |