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The IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation
SpyCEP-mediated chemokine degradation translates into more efficient spreading and increased severity of invasive Group A Streptococcus (GAS) infections, due to impaired neutrophil recruitment to the site of infection. SpyCEP is markedly up-regulated in invasive as compared to colonizing GAS isolate...
Autores principales: | Andreoni, Federica, Ogawa, Taiji, Ogawa, Mariko, Madon, Jerzy, Uchiyama, Satoshi, Schuepbach, Reto A., Zinkernagel, Annelies S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090674/ https://www.ncbi.nlm.nih.gov/pubmed/25071751 http://dx.doi.org/10.3389/fmicb.2014.00339 |
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