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Childhood body mass index and the risk of prostate cancer in adult men
BACKGROUND: Prostate cancer aetiology is poorly understood. It may have origins early in life; previously we found a positive association with childhood height. The effects of early life body mass index (BMI; kg m(−2)) on prostate cancer remain equivocal. We investigated if childhood BMI, independen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090733/ https://www.ncbi.nlm.nih.gov/pubmed/24867696 http://dx.doi.org/10.1038/bjc.2014.266 |
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author | Aarestrup, J Gamborg, M Cook, M B Sørensen, T I A Baker, J L |
author_facet | Aarestrup, J Gamborg, M Cook, M B Sørensen, T I A Baker, J L |
author_sort | Aarestrup, J |
collection | PubMed |
description | BACKGROUND: Prostate cancer aetiology is poorly understood. It may have origins early in life; previously we found a positive association with childhood height. The effects of early life body mass index (BMI; kg m(−2)) on prostate cancer remain equivocal. We investigated if childhood BMI, independently and adjusted for height, is positively associated with adult prostate cancer. METHODS: Subjects were a cohort of 125 208 boys formed from the Copenhagen School Health Records Register, born 1930–1969 with height and weight measurements at 7–13 years. Cases were identified through linkage to the Danish Cancer Registry. Cox proportional hazards regressions were performed. RESULTS: Overall, 3355 men were diagnosed with prostate cancer. Body mass index during childhood was positively associated with adult prostate cancer. The hazard ratio of prostate cancer was 1.06 (95% confidence interval (CI): 1.01–1.10) per BMI z-score at age 7, and 1.05 (95% CI: 1.01–1.10) per BMI z-score at age 13. Estimates were similar and significant at all other ages. However, adjustment for childhood height attenuated the associations at all but the youngest ages as most estimates became nonsignificant. CONCLUSIONS: These results suggest that at most childhood ages, BMI does not confer an additional risk for prostate cancer beyond that of height. |
format | Online Article Text |
id | pubmed-4090733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40907332015-07-01 Childhood body mass index and the risk of prostate cancer in adult men Aarestrup, J Gamborg, M Cook, M B Sørensen, T I A Baker, J L Br J Cancer Epidemiology BACKGROUND: Prostate cancer aetiology is poorly understood. It may have origins early in life; previously we found a positive association with childhood height. The effects of early life body mass index (BMI; kg m(−2)) on prostate cancer remain equivocal. We investigated if childhood BMI, independently and adjusted for height, is positively associated with adult prostate cancer. METHODS: Subjects were a cohort of 125 208 boys formed from the Copenhagen School Health Records Register, born 1930–1969 with height and weight measurements at 7–13 years. Cases were identified through linkage to the Danish Cancer Registry. Cox proportional hazards regressions were performed. RESULTS: Overall, 3355 men were diagnosed with prostate cancer. Body mass index during childhood was positively associated with adult prostate cancer. The hazard ratio of prostate cancer was 1.06 (95% confidence interval (CI): 1.01–1.10) per BMI z-score at age 7, and 1.05 (95% CI: 1.01–1.10) per BMI z-score at age 13. Estimates were similar and significant at all other ages. However, adjustment for childhood height attenuated the associations at all but the youngest ages as most estimates became nonsignificant. CONCLUSIONS: These results suggest that at most childhood ages, BMI does not confer an additional risk for prostate cancer beyond that of height. Nature Publishing Group 2014-07-01 2014-05-27 /pmc/articles/PMC4090733/ /pubmed/24867696 http://dx.doi.org/10.1038/bjc.2014.266 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Epidemiology Aarestrup, J Gamborg, M Cook, M B Sørensen, T I A Baker, J L Childhood body mass index and the risk of prostate cancer in adult men |
title | Childhood body mass index and the risk of prostate cancer in adult men |
title_full | Childhood body mass index and the risk of prostate cancer in adult men |
title_fullStr | Childhood body mass index and the risk of prostate cancer in adult men |
title_full_unstemmed | Childhood body mass index and the risk of prostate cancer in adult men |
title_short | Childhood body mass index and the risk of prostate cancer in adult men |
title_sort | childhood body mass index and the risk of prostate cancer in adult men |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090733/ https://www.ncbi.nlm.nih.gov/pubmed/24867696 http://dx.doi.org/10.1038/bjc.2014.266 |
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