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Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

BACKGROUND: Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin is a multifunctional protein and plays a key role in skin barrier formation. Loss-of-function mutations in the gene encoding filaggrin (FLG)...

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Detalles Bibliográficos
Autores principales:	Cole, Christian, Kroboth, Karin, Schurch, Nicholas J., Sandilands, Aileen, Sherstnev, Alexander, O'Regan, Grainne M., Watson, Rosemarie M., Irwin McLean, W.H., Barton, Geoffrey J., Irvine, Alan D., Brown, Sara J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2014
Materias:	Atopic Dermatitis and Skin Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090750/ https://www.ncbi.nlm.nih.gov/pubmed/24880632 http://dx.doi.org/10.1016/j.jaci.2014.04.021

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