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The chicken IL-1 family: evolution in the context of the studied vertebrate lineage

The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family h...

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Autores principales: Gibson, Mark S., Kaiser, Pete, Fife, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090809/
https://www.ncbi.nlm.nih.gov/pubmed/24863340
http://dx.doi.org/10.1007/s00251-014-0780-7
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author Gibson, Mark S.
Kaiser, Pete
Fife, Mark
author_facet Gibson, Mark S.
Kaiser, Pete
Fife, Mark
author_sort Gibson, Mark S.
collection PubMed
description The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily characterised in man and mouse. The genomes of most non-mammalian animal species sequenced so far possess all of the IL-1 receptor genes found in mammals. Yet, strikingly, very few of the ligands are identifiable in non-mammalian genomes. Our recent identification of two further IL-1 ligands in the chicken warranted a critical reappraisal of the evolution of this vitally important cytokine family. This review presents substantial data gathered across multiple, divergent metazoan genomes to unambiguously trace the origin of these genes. With the hypothesis that all of these genes, both ligands and receptors, were formed in a single ancient ancestor, extensive database mining revealed sufficient evidence to confirm this. It therefore suggests that the emergence of mammals is unrelated to the expansion of the IL-1 family. A thorough review of this cytokine family in the chicken, the most extensively studied amongst non-mammalian species, is also presented. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-014-0780-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-40908092014-07-10 The chicken IL-1 family: evolution in the context of the studied vertebrate lineage Gibson, Mark S. Kaiser, Pete Fife, Mark Immunogenetics Review The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily characterised in man and mouse. The genomes of most non-mammalian animal species sequenced so far possess all of the IL-1 receptor genes found in mammals. Yet, strikingly, very few of the ligands are identifiable in non-mammalian genomes. Our recent identification of two further IL-1 ligands in the chicken warranted a critical reappraisal of the evolution of this vitally important cytokine family. This review presents substantial data gathered across multiple, divergent metazoan genomes to unambiguously trace the origin of these genes. With the hypothesis that all of these genes, both ligands and receptors, were formed in a single ancient ancestor, extensive database mining revealed sufficient evidence to confirm this. It therefore suggests that the emergence of mammals is unrelated to the expansion of the IL-1 family. A thorough review of this cytokine family in the chicken, the most extensively studied amongst non-mammalian species, is also presented. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00251-014-0780-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-05-27 2014 /pmc/articles/PMC4090809/ /pubmed/24863340 http://dx.doi.org/10.1007/s00251-014-0780-7 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Gibson, Mark S.
Kaiser, Pete
Fife, Mark
The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title_full The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title_fullStr The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title_full_unstemmed The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title_short The chicken IL-1 family: evolution in the context of the studied vertebrate lineage
title_sort chicken il-1 family: evolution in the context of the studied vertebrate lineage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090809/
https://www.ncbi.nlm.nih.gov/pubmed/24863340
http://dx.doi.org/10.1007/s00251-014-0780-7
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