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Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and act...

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Autores principales: Su, Lee-Chun, Xie, Zhiwei, Zhang, Yi, Nguyen, Kytai Truong, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090902/
https://www.ncbi.nlm.nih.gov/pubmed/25023605
http://dx.doi.org/10.3389/fbioe.2014.00023
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author Su, Lee-Chun
Xie, Zhiwei
Zhang, Yi
Nguyen, Kytai Truong
Yang, Jian
author_facet Su, Lee-Chun
Xie, Zhiwei
Zhang, Yi
Nguyen, Kytai Truong
Yang, Jian
author_sort Su, Lee-Chun
collection PubMed
description Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70–80% suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50% for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired.
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spelling pubmed-40909022014-07-14 Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers Su, Lee-Chun Xie, Zhiwei Zhang, Yi Nguyen, Kytai Truong Yang, Jian Front Bioeng Biotechnol Bioengineering and Biotechnology Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70–80% suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50% for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired. Frontiers Media S.A. 2014-07-03 /pmc/articles/PMC4090902/ /pubmed/25023605 http://dx.doi.org/10.3389/fbioe.2014.00023 Text en Copyright © 2014 Su, Xie, Zhang, Nguyen and Yang. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Su, Lee-Chun
Xie, Zhiwei
Zhang, Yi
Nguyen, Kytai Truong
Yang, Jian
Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title_full Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title_fullStr Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title_full_unstemmed Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title_short Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers
title_sort study on the antimicrobial properties of citrate-based biodegradable polymers
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090902/
https://www.ncbi.nlm.nih.gov/pubmed/25023605
http://dx.doi.org/10.3389/fbioe.2014.00023
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