Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression

An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mic...

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Detalles Bibliográficos
Autores principales: Escobar, Giulia, Gentner, Bernhard, Naldini, Luigi, Mazzieri, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091049/
https://www.ncbi.nlm.nih.gov/pubmed/25097805
http://dx.doi.org/10.4161/onci.28696
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author Escobar, Giulia
Gentner, Bernhard
Naldini, Luigi
Mazzieri, Roberta
author_facet Escobar, Giulia
Gentner, Bernhard
Naldini, Luigi
Mazzieri, Roberta
author_sort Escobar, Giulia
collection PubMed
description An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression.
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spelling pubmed-40910492014-08-05 Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression Escobar, Giulia Gentner, Bernhard Naldini, Luigi Mazzieri, Roberta Oncoimmunology Author's View An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mice chimeric for these IFNα-expressing macrophages showed activation of innate and adaptive immune cells against breast cancer and inhibited disease progression. Landes Bioscience 2014-04-29 /pmc/articles/PMC4091049/ /pubmed/25097805 http://dx.doi.org/10.4161/onci.28696 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Escobar, Giulia
Gentner, Bernhard
Naldini, Luigi
Mazzieri, Roberta
Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title_full Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title_fullStr Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title_full_unstemmed Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title_short Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
title_sort engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091049/
https://www.ncbi.nlm.nih.gov/pubmed/25097805
http://dx.doi.org/10.4161/onci.28696
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