Engineered tumor-infiltrating macrophages as gene delivery vehicles for interferon-α activates immunity and inhibits breast cancer progression

An immunosuppressive tumor microenvironment is a cancer hallmark and a major impediment to successful immunotherapy. We engineered hematopoietic progenitors to target expression of an interferon-α (IFNα) transgene specifically to their monocytic progeny, including tumor-infiltrating macrophages. Mic...

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Detalles Bibliográficos
Autores principales: Escobar, Giulia, Gentner, Bernhard, Naldini, Luigi, Mazzieri, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091049/
https://www.ncbi.nlm.nih.gov/pubmed/25097805
http://dx.doi.org/10.4161/onci.28696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091049/
https://www.ncbi.nlm.nih.gov/pubmed/25097805
http://dx.doi.org/10.4161/onci.28696

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