Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins

Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TI...

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Detalles Bibliográficos
Autores principales: Gordon-Alonso, Monica, Demotte, Nathalie, van der Bruggen, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091051/
https://www.ncbi.nlm.nih.gov/pubmed/25097806
http://dx.doi.org/10.4161/onci.28783
Descripción
Sumario:Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TILs ex vivo with galectin antagonists for a few hours boosts their functions. Several galectin antagonists are currently available for clinical trials.

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