Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins

Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TI...

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Detalles Bibliográficos
Autores principales: Gordon-Alonso, Monica, Demotte, Nathalie, van der Bruggen, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091051/
https://www.ncbi.nlm.nih.gov/pubmed/25097806
http://dx.doi.org/10.4161/onci.28783
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author Gordon-Alonso, Monica
Demotte, Nathalie
van der Bruggen, Pierre
author_facet Gordon-Alonso, Monica
Demotte, Nathalie
van der Bruggen, Pierre
author_sort Gordon-Alonso, Monica
collection PubMed
description Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TILs ex vivo with galectin antagonists for a few hours boosts their functions. Several galectin antagonists are currently available for clinical trials.
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spelling pubmed-40910512014-08-05 Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins Gordon-Alonso, Monica Demotte, Nathalie van der Bruggen, Pierre Oncoimmunology Author's View Galectins released by tumor cells and macrophages can bind surface glycoproteins of tumor-infiltrating lymphocytes (TILs), forming glycoprotein-galectin lattices with immunosuppressive activities. Specifically, TILs covered by galectin-3 are unable to secrete cytokines after stimulation. Treating TILs ex vivo with galectin antagonists for a few hours boosts their functions. Several galectin antagonists are currently available for clinical trials. Landes Bioscience 2014-04-29 /pmc/articles/PMC4091051/ /pubmed/25097806 http://dx.doi.org/10.4161/onci.28783 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Gordon-Alonso, Monica
Demotte, Nathalie
van der Bruggen, Pierre
Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title_full Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title_fullStr Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title_full_unstemmed Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title_short Sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
title_sort sugars boost exhausted tumor-infiltrating lymphocytes by counteracting immunosuppressive activities of galectins
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091051/
https://www.ncbi.nlm.nih.gov/pubmed/25097806
http://dx.doi.org/10.4161/onci.28783
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